CYTOCHROME-P450 AND PARKINSONS-DISEASE - POOR PARAHYDROXYLATION OF PHENYTOIN

被引：21

作者：

FERRARI, MD

PEETERS, EAJ

HAAN, J

ROOS, RAC

VERMEY, P

DEWOLFF, FA

BURUMA, OJS

机构：

[1] UNIV HOSP LEIDEN,HOSP PHARM,2300 RC LEIDEN,NETHERLANDS

[2] UNIV HOSP LEIDEN,TOXICOL LAB,2300 RC LEIDEN,NETHERLANDS

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1990年 / 96卷 / 2-3期

关键词：

Cytochrome P450; Parkinson's disease; Phenytoin; Xenobiotic metabolism;

D O I：

10.1016/0022-510X(90)90128-A

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Phenytoin-parahydroxylation capacity was determined in 24 patients with Parkinson's disease (PD) and 17 controls. Different function of the phenytoin-metabolizing cytochrome P450 subsystem was found in 6 patients, but in none of the controls. These results add to previous studies suggesting a relation between the pathogenesis of PD and the function of cytochrome P450 subsystems. © 1990.

引用

页码：153 / 157

页数：5

共 20 条

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BARBEAU A, 1985, LANCET, V2, P1213

[2] SUSCEPTIBILITY IN PARKINSONS-DISEASE - OF MICE AND MEN [J].