INVOLVEMENT OF PURINE COMPOUNDS IN THE INOTROPIC ACTION OF MILRINONE

被引：12

作者：

DORIGO, P

GAION, RM

MARAGNO, I

机构：

[1] Department of Pharmacology, University of Padua, Padova, 35131

来源：

CARDIOVASCULAR DRUGS AND THERAPY | 1990年 / 4卷 / 02期

关键词：

adenosine; ATP; guinea-pig atria; inotropism; milrinone;

D O I：

10.1007/BF01857762

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In spontaneously beating atria from reserpinetreated guinea pigs, milrinone (1-100 μg/ml) induced a positive inotropic and chronotropic effect but was ineffective in preparations preincubated with adenosine deaminase (1 U/ml). Both in spontaneously beating and in electrically driven atria, ATP and adenosine evoked a dual effect: a first negative phase characterized by a reduction in contractile force, followed by a positive phase of increased inotropism. In these preparations milrinone inhibited the early negative influence exerted by purine compounds and amplified the following positive phase. These data suggest that the positive inotropic and chronotropic effect of milrinone may originate from its interference with endogenous purines. © 1990 Kluwer Academic Publishers.

引用

页码：509 / 513

页数：5

共 40 条

[1]

Alousi A.A., Canter J.M., Montenaro M.J., Et al., Cardiotonic activity of milrinone, a new and potent cardiac bipyridine, on the normal and failing heart of experimental animals, J Cardiovasc Pharmacol, 5, pp. 792-803, (1983)

[2]

Alousi A.A., Stankus G.P., Stuart J.C., Et al., Characterization of the cardiotonic effects of milrinone, a new and potent cardiac bipyridine on isolated tissues from several animal species, J Cardiovasc Pharmacol, 5, pp. 804-811, (1983)

[3]

Honerjager P., Schafer-Korting M., Reiter M., Involvement of cyclic AMP in the direct inotropic action of amrinone: Biochemical and functional evidence, Naunyn Schmiedebergs Arch Pharmacol, 381, pp. 112-120, (1981)

[4]

Endoh M., Yamashita A., Taira N., Positive inotropic effect of amrinone in relation to cyclic nucleotide metabolism in canine ventricular muscle, J Pharmacol Exp Ther, 221, pp. 775-783, (1982)

[5]

Earl C.Q., Linden J., Weglicki W.B., Biochemical mechanism for the inotropic effect of the cardiotonic drug milrinone, J Cardiovasc Pharmacol, 8, pp. 864-872, (1986)

[6]

Weishaar R.E., Burrows S.D., Kobylarz D.C., Et al., Multiple molecular forms of cyclic nucleotide phosphodiesterase in cardiac and smooth muscle and in platelets, Biochem Pharmacol, 35, pp. 787-800, (1986)

[7]

Silver P.J., Harris A.L., Fort D.J., Et al., Effects of the cardiotonic/vasodilator agents amrinone and milrinone, on phosphodiesterase (PDE) isoenzymes and contractile force in guinea pig cardiac and vascular tissue, Fed Proc, 46, (1987)

[8]

Ito M., Tanaka T., Saitoh M., Et al., Selective inhibition of cyclic AMP phosphodiesterase from various human tissues by milrinone, a potent cardiac bipyridine, Biochem Pharmacol, 37, pp. 2041-2044, (1988)

[9]

Alousi A.A., Farah A.E., Lesher G.Y., Et al., Cardiotonic activity of amrinone-Win 40680 (5-amino-3,4′-bipyridine-6-(IH)-one), Circ Res, 45, pp. 666-677, (1979)

[10]

Azari J., Huxtable R.J., Differential effects of amrinone on contractility and taurine influx in rat and guinea-pig hearts, Eur J Pharmacol, 67, pp. 347-353, (1980)

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