INVOLVEMENT OF PURINE COMPOUNDS IN THE INOTROPIC ACTION OF MILRINONE

被引：12

作者：

DORIGO, P

GAION, RM

MARAGNO, I

机构：

[1] Department of Pharmacology, University of Padua, Padova, 35131

来源：

CARDIOVASCULAR DRUGS AND THERAPY | 1990年 / 4卷 / 02期

关键词：

adenosine; ATP; guinea-pig atria; inotropism; milrinone;

D O I：

10.1007/BF01857762

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In spontaneously beating atria from reserpinetreated guinea pigs, milrinone (1-100 μg/ml) induced a positive inotropic and chronotropic effect but was ineffective in preparations preincubated with adenosine deaminase (1 U/ml). Both in spontaneously beating and in electrically driven atria, ATP and adenosine evoked a dual effect: a first negative phase characterized by a reduction in contractile force, followed by a positive phase of increased inotropism. In these preparations milrinone inhibited the early negative influence exerted by purine compounds and amplified the following positive phase. These data suggest that the positive inotropic and chronotropic effect of milrinone may originate from its interference with endogenous purines. © 1990 Kluwer Academic Publishers.

引用

页码：509 / 513

页数：5

共 40 条

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