KINDLING CAUSES CHANGES IN THE COMPOSITION OF THE ASTROCYTIC CYTOSKELETON

被引：37

作者：

KHURGEL, M

RACINE, RJ

IVY, GO

机构：

[1] UNIV TORONTO,DEPT ANAT & CELL BIOL,DIV LIFE SCI,1265 MIL TRAIL,SCARBOROUGH M1C 1A4,ONTARIO,CANADA

[2] MCMASTER UNIV,DEPT PSYCHOL,HAMILTON L8S 4L8,ONTARIO,CANADA

[3] UNIV TORONTO,DEPT PSYCHOL,SCARBOROUGH M1C 1A4,ONTARIO,CANADA

来源：

BRAIN RESEARCH | 1992年 / 592卷 / 1-2期

基金：

加拿大自然科学与工程研究理事会;

关键词：

KINDLING; ASTROCYTE; GLIAL FIBRILLARY ACIDIC PROTEIN; VIMENTIN; SEIZURE; AMYGDALA;

D O I：

10.1016/0006-8993(92)91694-A

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Changes in the astrocytic cytoskeleton were examined in amygdala kindled rats using immunocytochemical techniques. One week following kindling, there was a dramatic increase in immunoreactivity to glial fibrillary acidic protein and vimentin in astrocytes throughout amygdala, pyriform cortex and hippocampus bilaterally. Since these changes occurred in anatomical sites involved in the propagation of kindled seizures, the observed cytoskeletal reorganization in astrocytes may signify important functional alterations in the kindled brain.

引用

页码：338 / 342

页数：5