AN EFFICIENT SYNTHESIS OF (2S)N-BENZOYL-2-T-BUTYL-4-METHYLENEOXAZOLIDIN-5-ONE AND (2R)-N-BENZOYL-2-T-BUTYL-4-METHYLENEOXAZOLIDIN-5-ONE

被引：14

作者：

BECKWITH, ALJ

PYNE, SG

DIKIC, B

CHAI, CLL

GORDON, PA

SKELTON, BW

TOZER, MJ

WHITE, AH

机构：

[1] UNIV WOLLONGONG,DEPT CHEM,WOLLONGONG,NSW 2522,AUSTRALIA

[2] UNIV WESTERN AUSTRALIA,DEPT CHEM,NEDLANDS,WA 6009,AUSTRALIA

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 1993年 / 46卷 / 09期

关键词：

D O I：

10.1071/CH9931425

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient synthesis of the title compounds in high enantiomeric purity (>98%) involves bromination under photolytic conditions of (2S)- or (2R)-oxazolidinones derived from (S)-alanine followed by treatment of the products with sodium iodide in refluxing acetone. A room-temperature single-crystal X-ray study of (2S,4Z)-N-benzoyl-4-bromomethylene-2-t-butyloxazolidin-5-one is recorded.

引用

页码：1425 / 1430

页数：6