Assessing the Costs and Cost-Effectiveness of Genomic Sequencing

被引：85

作者：

Christensen, Kurt D. ^{[1
]}

Dukhovny, Dmitry ^{[2
]}

Siebert, Uwe ^{[3
,4
,5
]}

Green, Robert C. ^{[6
]}

机构：

[1] Harvard Med Sch, Dept Med, Brigham & Womens Hosp, Boston, MA 02115 USA

[2] Oregon Hlth & Sci Univ, Dept Pediat, Portland, OR 97239 USA

[3] Univ Hlth Sci Med Informat & Technol, Dept Publ Hlth Med Decis Making & Hlth Technol As, A-6060 Hall In Tirol, Austria

[4] Harvard Sch Publ Hlth, Dept Hlth Policy & Management, Boston, MA 02115 USA

[5] Harvard Med Sch, Dept Radiol, Massachusetts Gen Hosp, Boston, MA 02114 USA

[6] Harvard Med Sch, Dept Med, Brigham & Womens Hosp, Partners Personalized Med, Boston, MA 02115 USA

来源：

JOURNAL OF PERSONALIZED MEDICINE | 2015年 / 5卷 / 04期

基金：

美国国家卫生研究院;

关键词：

whole genomic sequencing; whole exome sequencing; cost; cost-effectiveness;

D O I：

10.3390/jpm5040470

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Despite dramatic drops in DNA sequencing costs, concerns are great that the integration of genomic sequencing into clinical settings will drastically increase health care expenditures. This commentary presents an overview of what is known about the costs and cost-effectiveness of genomic sequencing. We discuss the cost of germline genomic sequencing, addressing factors that have facilitated the decrease in sequencing costs to date and anticipating the factors that will drive sequencing costs in the future. We then address the cost-effectiveness of diagnostic and pharmacogenomic applications of genomic sequencing, with an emphasis on the implications for secondary findings disclosure and the integration of genomic sequencing into general patient care. Throughout, we ground the discussion by describing efforts in the MedSeq Project, an ongoing randomized controlled clinical trial, to understand the costs and cost-effectiveness of integrating whole genome sequencing into cardiology and primary care settings.

引用

页码：470 / 486

页数：17

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