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WHY ION-PAIR REVERSAL BY PROTEIN ENGINEERING IS UNLIKELY TO SUCCEED
被引:95
作者
:
HWANG, JK
论文数:
0
引用数:
0
h-index:
0
HWANG, JK
WARSHEL, A
论文数:
0
引用数:
0
h-index:
0
WARSHEL, A
机构
:
来源
:
NATURE
|
1988年
/ 334卷
/ 6179期
关键词
:
D O I
:
10.1038/334270a0
中图分类号
:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号
:
07 ;
0710 ;
09 ;
摘要
:
引用
收藏
页码:270 / 272
页数:3
相关论文
共 20 条
[1]
ARNONE A, 1982, MOL STRUCTURE BIOL A, P57
[2]
REVERSAL OF SUBSTRATE CHARGE SPECIFICITY BY SITE-DIRECTED MUTAGENESIS OF ASPARTATE-AMINOTRANSFERASE
[J].
CRONIN, CN
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF BERKELEY LAWRENCE BERKELEY LAB,DEPT BIOCHEM,BERKELEY,CA 94720
CRONIN, CN
;
MALCOLM, BA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF BERKELEY LAWRENCE BERKELEY LAB,DEPT BIOCHEM,BERKELEY,CA 94720
MALCOLM, BA
;
KIRSCH, JF
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF BERKELEY LAWRENCE BERKELEY LAB,DEPT BIOCHEM,BERKELEY,CA 94720
KIRSCH, JF
.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,
1987,
109
(07)
:2222
-2223
[3]
CRONIN CN, UNPUB BIOCHEMISTRY
[4]
CALCULATION OF ELECTROSTATIC POTENTIALS IN AN ENZYME ACTIVE-SITE
[J].
GILSON, MK
论文数:
0
引用数:
0
h-index:
0
GILSON, MK
;
HONIG, BH
论文数:
0
引用数:
0
h-index:
0
HONIG, BH
.
NATURE,
1987,
330
(6143)
:84
-86
[5]
SELECTIVE ALTERATION OF SUBSTRATE-SPECIFICITY BY REPLACEMENT OF ASPARTIC ACID-189 WITH LYSINE IN THE BINDING POCKET OF TRYPSIN
[J].
GRAF, L
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN FRANCISCO,HORMONE RES INST,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143
GRAF, L
;
CRAIK, CS
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN FRANCISCO,HORMONE RES INST,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143
CRAIK, CS
;
PATTHY, A
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN FRANCISCO,HORMONE RES INST,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143
PATTHY, A
;
ROCZNIAK, S
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN FRANCISCO,HORMONE RES INST,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143
ROCZNIAK, S
;
FLETTERICK, RJ
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN FRANCISCO,HORMONE RES INST,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143
FLETTERICK, RJ
;
RUTTER, WJ
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN FRANCISCO,HORMONE RES INST,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143
RUTTER, WJ
.
BIOCHEMISTRY,
1987,
26
(09)
:2616
-2623
[6]
SEMIQUANTITATIVE CALCULATIONS OF CATALYTIC FREE-ENERGIES IN GENETICALLY MODIFIED ENZYMES
[J].
HWANG, JK
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SO CALIF,DEPT CHEM,LOS ANGELES,CA 90089
UNIV SO CALIF,DEPT CHEM,LOS ANGELES,CA 90089
HWANG, JK
;
WARSHEL, A
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SO CALIF,DEPT CHEM,LOS ANGELES,CA 90089
UNIV SO CALIF,DEPT CHEM,LOS ANGELES,CA 90089
WARSHEL, A
.
BIOCHEMISTRY,
1987,
26
(10)
:2669
-2673
[7]
MECHANISM OF ACTION OF ASPARTATE-AMINOTRANSFERASE PROPOSED ON THE BASIS OF ITS SPATIAL STRUCTURE
[J].
KIRSCH, JF
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BASEL,BIOCTR,STRUKTURBIOL ABT,CH-4056 BASEL,SWITZERLAND
KIRSCH, JF
;
EICHELE, G
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BASEL,BIOCTR,STRUKTURBIOL ABT,CH-4056 BASEL,SWITZERLAND
EICHELE, G
;
FORD, GC
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BASEL,BIOCTR,STRUKTURBIOL ABT,CH-4056 BASEL,SWITZERLAND
FORD, GC
;
VINCENT, MG
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BASEL,BIOCTR,STRUKTURBIOL ABT,CH-4056 BASEL,SWITZERLAND
VINCENT, MG
;
JANSONIUS, JN
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BASEL,BIOCTR,STRUKTURBIOL ABT,CH-4056 BASEL,SWITZERLAND
JANSONIUS, JN
;
GEHRING, H
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BASEL,BIOCTR,STRUKTURBIOL ABT,CH-4056 BASEL,SWITZERLAND
GEHRING, H
;
CHRISTEN, P
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BASEL,BIOCTR,STRUKTURBIOL ABT,CH-4056 BASEL,SWITZERLAND
CHRISTEN, P
.
JOURNAL OF MOLECULAR BIOLOGY,
1984,
174
(03)
:497
-525
[8]
MONTE-CARLO DETERMINATION OF THE FREE-ENERGY AND INTERNAL ENERGY OF HYDRATION FOR THE ALA DIPEPTIDE AT 25-DEGREES-C
[J].
MEZEI, M
论文数:
0
引用数:
0
h-index:
0
机构:
CUNY HUNTER COLL,DEPT CHEM,NEW YORK,NY 10021
CUNY HUNTER COLL,DEPT CHEM,NEW YORK,NY 10021
MEZEI, M
;
MEHROTRA, PK
论文数:
0
引用数:
0
h-index:
0
机构:
CUNY HUNTER COLL,DEPT CHEM,NEW YORK,NY 10021
CUNY HUNTER COLL,DEPT CHEM,NEW YORK,NY 10021
MEHROTRA, PK
;
BEVERIDGE, DL
论文数:
0
引用数:
0
h-index:
0
机构:
CUNY HUNTER COLL,DEPT CHEM,NEW YORK,NY 10021
CUNY HUNTER COLL,DEPT CHEM,NEW YORK,NY 10021
BEVERIDGE, DL
.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,
1985,
107
(08)
:2239
-2245
[9]
STABILIZATION OF CHARGES ON ISOLATED IONIC GROUPS SEQUESTERED IN PROTEINS BY POLARIZED PEPTIDE UNITS
[J].
QUIOCHO, FA
论文数:
0
引用数:
0
h-index:
0
机构:
BAYLOR COLL MED,DEPT BIOCHEM,HOUSTON,TX 77030
QUIOCHO, FA
;
SACK, JS
论文数:
0
引用数:
0
h-index:
0
机构:
BAYLOR COLL MED,DEPT BIOCHEM,HOUSTON,TX 77030
SACK, JS
;
VYAS, NK
论文数:
0
引用数:
0
h-index:
0
机构:
BAYLOR COLL MED,DEPT BIOCHEM,HOUSTON,TX 77030
VYAS, NK
.
NATURE,
1987,
329
(6139)
:561
-564
[10]
FREE-ENERGY PERTURBATION CALCULATIONS ON BINDING AND CATALYSIS AFTER MUTATING ASN-155 IN SUBTILISIN
[J].
RAO, SN
论文数:
0
引用数:
0
h-index:
0
RAO, SN
;
SINGH, UC
论文数:
0
引用数:
0
h-index:
0
SINGH, UC
;
BASH, PA
论文数:
0
引用数:
0
h-index:
0
BASH, PA
;
KOLLMAN, PA
论文数:
0
引用数:
0
h-index:
0
KOLLMAN, PA
.
NATURE,
1987,
328
(6130)
:551
-554
←
1
2
→
共 20 条
[1]
ARNONE A, 1982, MOL STRUCTURE BIOL A, P57
[2]
REVERSAL OF SUBSTRATE CHARGE SPECIFICITY BY SITE-DIRECTED MUTAGENESIS OF ASPARTATE-AMINOTRANSFERASE
[J].
CRONIN, CN
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF BERKELEY LAWRENCE BERKELEY LAB,DEPT BIOCHEM,BERKELEY,CA 94720
CRONIN, CN
;
MALCOLM, BA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF BERKELEY LAWRENCE BERKELEY LAB,DEPT BIOCHEM,BERKELEY,CA 94720
MALCOLM, BA
;
KIRSCH, JF
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF BERKELEY LAWRENCE BERKELEY LAB,DEPT BIOCHEM,BERKELEY,CA 94720
KIRSCH, JF
.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,
1987,
109
(07)
:2222
-2223
[3]
CRONIN CN, UNPUB BIOCHEMISTRY
[4]
CALCULATION OF ELECTROSTATIC POTENTIALS IN AN ENZYME ACTIVE-SITE
[J].
GILSON, MK
论文数:
0
引用数:
0
h-index:
0
GILSON, MK
;
HONIG, BH
论文数:
0
引用数:
0
h-index:
0
HONIG, BH
.
NATURE,
1987,
330
(6143)
:84
-86
[5]
SELECTIVE ALTERATION OF SUBSTRATE-SPECIFICITY BY REPLACEMENT OF ASPARTIC ACID-189 WITH LYSINE IN THE BINDING POCKET OF TRYPSIN
[J].
GRAF, L
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN FRANCISCO,HORMONE RES INST,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143
GRAF, L
;
CRAIK, CS
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN FRANCISCO,HORMONE RES INST,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143
CRAIK, CS
;
PATTHY, A
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN FRANCISCO,HORMONE RES INST,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143
PATTHY, A
;
ROCZNIAK, S
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN FRANCISCO,HORMONE RES INST,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143
ROCZNIAK, S
;
FLETTERICK, RJ
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN FRANCISCO,HORMONE RES INST,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143
FLETTERICK, RJ
;
RUTTER, WJ
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN FRANCISCO,HORMONE RES INST,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143
RUTTER, WJ
.
BIOCHEMISTRY,
1987,
26
(09)
:2616
-2623
[6]
SEMIQUANTITATIVE CALCULATIONS OF CATALYTIC FREE-ENERGIES IN GENETICALLY MODIFIED ENZYMES
[J].
HWANG, JK
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SO CALIF,DEPT CHEM,LOS ANGELES,CA 90089
UNIV SO CALIF,DEPT CHEM,LOS ANGELES,CA 90089
HWANG, JK
;
WARSHEL, A
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SO CALIF,DEPT CHEM,LOS ANGELES,CA 90089
UNIV SO CALIF,DEPT CHEM,LOS ANGELES,CA 90089
WARSHEL, A
.
BIOCHEMISTRY,
1987,
26
(10)
:2669
-2673
[7]
MECHANISM OF ACTION OF ASPARTATE-AMINOTRANSFERASE PROPOSED ON THE BASIS OF ITS SPATIAL STRUCTURE
[J].
KIRSCH, JF
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BASEL,BIOCTR,STRUKTURBIOL ABT,CH-4056 BASEL,SWITZERLAND
KIRSCH, JF
;
EICHELE, G
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BASEL,BIOCTR,STRUKTURBIOL ABT,CH-4056 BASEL,SWITZERLAND
EICHELE, G
;
FORD, GC
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BASEL,BIOCTR,STRUKTURBIOL ABT,CH-4056 BASEL,SWITZERLAND
FORD, GC
;
VINCENT, MG
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BASEL,BIOCTR,STRUKTURBIOL ABT,CH-4056 BASEL,SWITZERLAND
VINCENT, MG
;
JANSONIUS, JN
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BASEL,BIOCTR,STRUKTURBIOL ABT,CH-4056 BASEL,SWITZERLAND
JANSONIUS, JN
;
GEHRING, H
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BASEL,BIOCTR,STRUKTURBIOL ABT,CH-4056 BASEL,SWITZERLAND
GEHRING, H
;
CHRISTEN, P
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV BASEL,BIOCTR,STRUKTURBIOL ABT,CH-4056 BASEL,SWITZERLAND
CHRISTEN, P
.
JOURNAL OF MOLECULAR BIOLOGY,
1984,
174
(03)
:497
-525
[8]
MONTE-CARLO DETERMINATION OF THE FREE-ENERGY AND INTERNAL ENERGY OF HYDRATION FOR THE ALA DIPEPTIDE AT 25-DEGREES-C
[J].
MEZEI, M
论文数:
0
引用数:
0
h-index:
0
机构:
CUNY HUNTER COLL,DEPT CHEM,NEW YORK,NY 10021
CUNY HUNTER COLL,DEPT CHEM,NEW YORK,NY 10021
MEZEI, M
;
MEHROTRA, PK
论文数:
0
引用数:
0
h-index:
0
机构:
CUNY HUNTER COLL,DEPT CHEM,NEW YORK,NY 10021
CUNY HUNTER COLL,DEPT CHEM,NEW YORK,NY 10021
MEHROTRA, PK
;
BEVERIDGE, DL
论文数:
0
引用数:
0
h-index:
0
机构:
CUNY HUNTER COLL,DEPT CHEM,NEW YORK,NY 10021
CUNY HUNTER COLL,DEPT CHEM,NEW YORK,NY 10021
BEVERIDGE, DL
.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,
1985,
107
(08)
:2239
-2245
[9]
STABILIZATION OF CHARGES ON ISOLATED IONIC GROUPS SEQUESTERED IN PROTEINS BY POLARIZED PEPTIDE UNITS
[J].
QUIOCHO, FA
论文数:
0
引用数:
0
h-index:
0
机构:
BAYLOR COLL MED,DEPT BIOCHEM,HOUSTON,TX 77030
QUIOCHO, FA
;
SACK, JS
论文数:
0
引用数:
0
h-index:
0
机构:
BAYLOR COLL MED,DEPT BIOCHEM,HOUSTON,TX 77030
SACK, JS
;
VYAS, NK
论文数:
0
引用数:
0
h-index:
0
机构:
BAYLOR COLL MED,DEPT BIOCHEM,HOUSTON,TX 77030
VYAS, NK
.
NATURE,
1987,
329
(6139)
:561
-564
[10]
FREE-ENERGY PERTURBATION CALCULATIONS ON BINDING AND CATALYSIS AFTER MUTATING ASN-155 IN SUBTILISIN
[J].
RAO, SN
论文数:
0
引用数:
0
h-index:
0
RAO, SN
;
SINGH, UC
论文数:
0
引用数:
0
h-index:
0
SINGH, UC
;
BASH, PA
论文数:
0
引用数:
0
h-index:
0
BASH, PA
;
KOLLMAN, PA
论文数:
0
引用数:
0
h-index:
0
KOLLMAN, PA
.
NATURE,
1987,
328
(6130)
:551
-554
←
1
2
→