THE EFFECT OF CHYLOMICRON REMNANTS ON BILE-ACID SYNTHESIS IN CULTURED RAT HEPATOCYTES

被引：8

作者：

FRY, RP

MAYES, PA

SUCKLING, KE

BOTHAM, KM

机构：

[1] UNIV LONDON ROYAL VET COLL,DEPT VET BASIC SCI,ROYAL COLL ST,LONDON NW1 0TU,ENGLAND

[2] SK&F RES LTD,WELWYN GARDEN CIT,ENGLAND

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1042卷 / 03期

关键词：

(Cultured rat hepatocyte); Bile acid synthesis; Cholesterol; Chylomicron; Chylomicron remnant;

D O I：

10.1016/0005-2760(90)90173-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of chylomicron remnants on bile acid synthesis in isolated rat hepatocytes in monolayer cultures was investigated. Production of bile acids by the cells in the presence of chylomicron remnants at a cholesterol concentration of 7.8-9 nmol/ml was increased by approx. 75% after 17 h and 25% after 24 h incubation. Similar concentrations of cholesterol added to the cells in the form of chylomicrons had no significant effect on bile acid synthesis. These results suggest that cholesterol taken up in chylomicron remnants may be an important source of substrate for bile acid synthesis. © 1990.

引用

页码：413 / 416

页数：4

共 32 条

[21] EFFECTS OF ANTI-MICROTUBULAR AGENTS AND CYCLOHEXIMIDE ON METABOLISM OF CHYLOMICRON CHOLESTERYL ESTERS BY HEPATOCYTE SUSPENSIONS
NILSSON, A
[J]. BIOCHEMICAL JOURNAL, 1977, 162 (02) : 367 - 377
[22] INVITRO MODEL FOR CATABOLISM OF RAT CHYLOMICRONS
NOEL, SP
DOLPHIN, PJ
RUBINSTEIN, D
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1975, 63 (03) : 764 - 772
[23] STEROL BALANCE STUDIES IN RAT - EFFECTS OF DIETARY CHOLESTEROL AND BETA-SITOSTEROL ON STEROL BALANCE AND RATE-LIMITING ENZYMES OF STEROL-METABOLISM
RAICHT, RF
COHEN, BI
SHEFER, S
MOSBACH, EH
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1975, 388 (03) : 374 - 384
[24] REDGRAVE T G, 1970, Journal of Clinical Investigation, V49, P465, DOI 10.1172/JCI106255
[25] REDGRAVE TG, 1983, INT REV PHYSIOL, V28, P103
[26] SEIDEL J, 1981, J CLIN CHEM, V19, P838
[27] SHEFER S, 1981, J LIPID RES, V22, P532
[28] SIPERSTEIN MD, 1952, P SOC EXP BIOL MED, V81, P720, DOI 10.3181/00379727-81-19999
[29] BILE-ACID SYNTHESIS AND INTRACELLULAR AND EXTRACELLULAR CHOLESTEROL CONCENTRATIONS IN ISOLATED RAT HEPATOCYTES - THE EFFECT OF DIETARY-CHOLESTEROL
SUTTON, CM
BOTHAM, KM
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 1001 (02) : 210 - 217
[30] WAHLEFELD AW, 1974, METHOD ENZYMAT AN, P1831

← 1 2 3 4 →