THE EFFECT OF CHYLOMICRON REMNANTS ON BILE-ACID SYNTHESIS IN CULTURED RAT HEPATOCYTES

被引:8
作者
FRY, RP
MAYES, PA
SUCKLING, KE
BOTHAM, KM
机构
[1] UNIV LONDON ROYAL VET COLL,DEPT VET BASIC SCI,ROYAL COLL ST,LONDON NW1 0TU,ENGLAND
[2] SK&F RES LTD,WELWYN GARDEN CIT,ENGLAND
关键词
(Cultured rat hepatocyte); Bile acid synthesis; Cholesterol; Chylomicron; Chylomicron remnant;
D O I
10.1016/0005-2760(90)90173-U
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The effect of chylomicron remnants on bile acid synthesis in isolated rat hepatocytes in monolayer cultures was investigated. Production of bile acids by the cells in the presence of chylomicron remnants at a cholesterol concentration of 7.8-9 nmol/ml was increased by approx. 75% after 17 h and 25% after 24 h incubation. Similar concentrations of cholesterol added to the cells in the form of chylomicrons had no significant effect on bile acid synthesis. These results suggest that cholesterol taken up in chylomicron remnants may be an important source of substrate for bile acid synthesis. © 1990.
引用
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页码:413 / 416
页数:4
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