ANTIVIRAL OPTICALLY PURE DIOXOLANE PURINE NUCLEOSIDES ANALOGS

被引：22

作者：

SIDDIQUI, MA

BROWN, WL

NGUYENBA, N

DIXIT, DM

MANSOUR, TS

HOOKER, E

VINER, KC

CAMERON, JM

机构：

[1] BIOCHEM THERAPEUT, 531 BLVD PRAIRIES, LAVAL H7V 1B7, PQ, CANADA

[2] GLAXO GRP RES LTD, DEPT VIROL, GREENFORD RD, GREENFORD UB6 0HE, MIDDX, ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(00)80014-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Selective deamination of (+/-) ci., 2,6-diaminopurine dioxolane nucleoside produces the (-) guanine analogue having the 2R,4R absolute stereochemistry. The (+/-) cis-adenine analogue generates the 2R,4R hypoxanthinyl derivative. Asymmetric synthesis of purine dioxolanes have been developed. The (-) adenine and (-) guanine compounds 6 and 7 emerged as potent inhibitors of the HIV-1 replication in vitro.

引用

页码：1543 / 1546

页数：4

共 19 条

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