PREPARATION OF (2R,3S)-BETA-HYDROXY-ALPHA-AMINO ACIDS BY USE OF A NOVEL STREPTOMYCES ALDOLASE AS A RESOLVING AGENT FOR RACEMIC MATERIAL

被引：17

作者：

HERBERT, RB ^{[1
]}

WILKINSON, B ^{[1
]}

ELLAMES, GJ ^{[1
]}

机构：

[1] STERLING WINTHROP RES CTR,DEPT CHEM DEV,STERLING WINTHROP PHARM RES DIV,NE66 2JH ALNWICK,NORTHD,ENGLAND

来源：

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE | 1994年 / 72卷 / 01期

关键词：

D O I：

10.1139/v94-018

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A unique aldolase, which was isolated from Streptomyces amakusaensis, is used to catalyse a reverse aldol reaction on representative racemic beta-hydroxy-alpha-amino acids (3-6) to give samples of the (2R,3S)-(D-threo)-enantiomers with excellent enantiomeric purity.

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页码：114 / 117

页数：4

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