SUBSTITUENT EFFECTS IN CHEMICAL CARCINOGENESIS - METHYL-DERIVATIVES OF THE BENZACRIDINES

被引：42

作者：

SMITH, IA

SEYBOLD, PG

机构：

[1] WRIGHT STATE UNIV, DEPT CHEM, DAYTON, OH 45435 USA

[2] WRIGHT STATE UNIV, DEPT BIOL CHEM, DAYTON, OH 45435 USA

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1979年 / 16卷 / 03期

关键词：

D O I：

10.1002/jhet.5570160302

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An explanation for the different carcinogenic potencies observed among methyl derivatives of the angular benzacridines is given in terms of the tendencies of these compounds to undergo specific metabolic activating reactions analogous to those of polycyclic aromatic hydrocarbons. Theoretical reactivity indices representing these reactions correlate with the carcinogenic activities of these compounds. Copyright © 1979 Journal of Heterocyclic Chemistry

引用

页码：421 / 425

页数：5

共 20 条

[11]

LIBERMAN.C, 1968, CR SOC BIOL, V162, P835

[12] SUPERDELOCALIZABILITY INDICES AND PULLMAN THEORY OF CHEMICAL CARCINOGENESIS [J].