THE CROSS-REACTIVITY AND IMMUNOLOGY OF BETA-LACTAM ANTIBIOTICS

被引：36

作者：

KISHIYAMA, JL ^{[1
]}

ADELMAN, DC ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,DIV ALLERGY & IMMUNOL,535 PARNASSUS,U426,SAN FRANCISCO,CA 94143

来源：

DRUG SAFETY | 1994年 / 10卷 / 04期

关键词：

D O I：

10.2165/00002018-199410040-00006

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Allergic reactions to beta-lactam antibiotics are well described; however, only the immunochemistry of penicillin has been characterised. Although the major determinant of benzylpenicillin (penicillin G) is commercially licensed for diagnostic applications, minor determinants are only available at some centres to be used for identification of hypersensitive individuals. Cephalosporins share a common bicyclic nuclear structure with penicillin and most cross-reactivity is generated to the beta-lactam ring. It is not possible to determine the actual incidence of cross-reactivity between penicillins and cephalosporins, but evidence suggests the true rate is lower than usually appreciated. In vitro testing demonstrates extensive cross-reactivity between penicillin and the carbapenems. Although the rate of clinical cross-reactivity is not known, imipenem should not be given to patients with proven penicillin hypersensitivity. In contrast, aztreonam and the monobactams can be safely given to penicillin-allergic patients.

引用

页码：318 / 327

页数：10

共 38 条

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