INTERLEUKIN-1 MEDIATES BEHAVIORAL BUT NOT METABOLIC EFFECTS OF TUMOR-NECROSIS-FACTOR-ALPHA IN MICE

被引：71

作者：

BLUTHE, RM ^{[1
]}

DANTZER, R ^{[1
]}

KELLEY, KW ^{[1
]}

机构：

[1] UNIV ILLINOIS,DEPT ANIM SCI,IMMUNOPHYSIOL LAB,PLANT & ANIM BIOTECHNOL LAB,URBANA,IL 61801

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 209卷 / 03期

关键词：

TUMOR NECROSIS FACTOR; INTERLEUKIN-1; INTERLEUKIN-1 RECEPTOR ANTAGONISTS; SOCIAL BEHAVIOR; BODY WEIGHT; (MOUSE);

D O I：

10.1016/0014-2999(91)90184-R

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Recombinant human tumor necrosis factor-alpha (TNF-alpha) decreases social exploration and induces weight loss in mice in a dose- and time-dependent manner (2.5-40-mu-g/mouse). To assess the role of interleukin-I (IL-1) in these effects, mice pretreated with IL-1 receptor antagonist (IL-1ra, 500-mu-g/mouse, i.p.) were injected with 25-mu-g TNF-alpha. Pretreatment with IL-1ra antagonized the depressive effects of TNF-alpha on behaviour but only partially attenuated the weight loss induced by this cytokine. These results suggest that TNF-alpha-induced sickness behaviour is mediated mainly by endogenously released IL-1 whereas metabolic changes are dependent on the release of other additional cytokines.

引用

页码：281 / 283

页数：3

共 9 条

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