EFFICIENT PROCEDURE FOR THE PREPARATION OF CHIRAL BETA-SUBSTITUTED (E)-CROTYLSILANES - APPLICATION OF A RHODIUM(II) CATALYZED SILYLFORMYLATION OF TERMINAL ALKYNES

被引：21

作者：

JAIN, NF ^{[1
]}

CIRILLO, PF ^{[1
]}

SCHAUS, JV ^{[1
]}

PANEK, JS ^{[1
]}

机构：

[1] BOSTON UNIV,DEPT CHEM,METCALF CTR SCI & ENGN,BOSTON,MA 02215

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 48期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0040-4039(95)01894-N

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Functionalized beta-substituted (E)-crotylsilanes (R)-7 and (S)-8, bearing an alkyl or aryl group adjacent to the stereogenic C-Si center have been synthesized in an efficient four-step procedure initiated with a regio- and stereoselective silylformylation of a terminal alkyne catalyzed by dirhodium(II) perfluorobutyrate.

引用

页码：8723 / 8726

页数：4

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