NUMEROUS GLIAL FIBRILLARY TANGLES IN OLIGODENDROGLIA IN CASES OF SUBACUTE SCLEROSING PANENCEPHALITIS WITH NEUROFIBRILLARY TANGLES

被引：41

作者：

IKEDA, K

AKIYAMA, H

KONDO, H

ARAI, T

ARAI, N

YAGISHITA, S

机构：

[1] TOKYO METROPOLITAN MATSUZAWA HOSP,SETAGAYA KU,TOKYO 156,JAPAN

[2] TOKYO METROPOLITAN INST NEUROSCI,DEPT CLIN NEUROPATHOL,FUCHU,TOKYO 183,JAPAN

[3] KANAGAWA REHABIL CTR,DIV PATHOL,ATSUGI,KANAGAWA,JAPAN

来源：

NEUROSCIENCE LETTERS | 1995年 / 194卷 / 1-2期

关键词：

GLIAL FIBRILLARY TANGLE; OLIGODENDROGLIA; NEUROFIBRILLARY TANGLE; TAU PROTEIN; SUBACUTE SCLEROSING PANENCEPHALITIS;

D O I：

10.1016/0304-3940(95)11713-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Both neurons and oligodendroglia are preferentially infected in subacute sclerosing panencephalitis (SSPE). Massive argyrophilic and tau-positive glial fibrillary tangles (GFT) were found in oligodendroglia in two autopsy cases of SSPE with neurofibrillary tangles (NFT). GFT shared common phosphorylated tau-epitopes with NFT, but were negative for ubiquitin. Electron microscopically, GFT consisted of compact bundles of irregularly woven tubules. Thus, GFT in SSPE differed from NFT showing regular constriction of tubules and from GFT in some other cytoskeletal disorders in which GFT reportedly consisted of straight tubules.

引用

页码：133 / 135

页数：3

共 10 条

[1] CORTICAL AND SUBCORTICAL ARGYROPHILIC GRAINS CHARACTERIZE A DISEASE ASSOCIATED WITH ADULT ONSET DEMENTIA [J].