SYMBIOTIC APPROACH TO DRUG DESIGN - N-[(4-CHLORO-3-SULFAMOYLBENZAMIDO)-ETHYL]PROPANOLAMINE DERIVATIVES AS BETA-ADRENERGIC BLOCKING-AGENTS WITH DIURETIC ACTIVITY

A series of oxypropanolamines and iminoxypropanolamines, in which the aminic substituent was the 2-(4-chloro-3-sulfamoylbenzamido)-ethyl group, were synthesized as potential beta-blocker/diuretic agents. All of these compounds were tested for beta-1-adrenoceptor affinity and beta-blocking potency. For the most active compounds, diuretic and antihypertensive properties as well as affinity for alpha-1-adrenoceptors were also investigated. Compounds 4 and 10 were found to display contemporaneously beta-blocking, diuretic and antihypertensive activities.