EXPERIMENTAL-STUDY OF THE PRODUCTION-RATE OF PURE ENANTIOMERS FROM RACEMIC MIXTURES

被引：13

作者：

JACOBSON, SC

GUIOCHON, G

机构：

[1] UNIV TENNESSEE,DEPT CHEM,KNOXVILLE,TN 37996

[2] OAK RIDGE NATL LAB,DIV ANALYT CHEM,OAK RIDGE,TN 37831

来源：

JOURNAL OF CHROMATOGRAPHY | 1992年 / 590卷 / 01期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/0021-9673(92)87012-W

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Elution band profiles were determined experimentally for the racemic mixture Of D- and L-mandelic acid on a bovine serum albumin chemically bonded phase. The results show significantly different profiles for a given amount of either isomer, whether pure or in the racemic mixture. The production rate at 99% purity is more than one order of magnitude higher under overlapping band than under touching band conditions. In the former instance, the recovery yield and production rate are always higher for the less retained enantiomer.

引用

页码：119 / 126

页数：8