DIVERGENT STEREOSELECTIVITY IN THE REDUCTION OF ALPHA,BETA-EPOXY KETONES USING HYDRIDOSILICATES

被引：32

作者：

HOJO, M ^{[1
]}

FUJII, A ^{[1
]}

MURAKAMI, C ^{[1
]}

AIHARA, H ^{[1
]}

HOSOMI, A ^{[1
]}

机构：

[1] UNIV TSUKUBA,DEPT CHEM,TSUKUBA,IBARAKI 305,JAPAN

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 04期

关键词：

D O I：

10.1016/0040-4039(94)02255-A

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha,beta-Epoxy ketones are reduced by trimethoxysilane in the presence of a catalytic amount of lithium methoxide to yield the corresponding alcohols. This reaction system reveals divergent selectivity depending on the solvent; both anti-selectivity and syn-selectivity are observed in less polar Et(2)O and in polar HMPA, respectively.

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页码：571 / 574

页数：4

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