THE CHEMISTRY OF CONTACT ALLERGY - WHY IS A MOLECULE ALLERGENIC

被引：104

作者：

BASKETTER, D

DOOMSGOOSSENS, A

KARLBERG, AT

LEPOITTEVIN, JP

机构：

[1] UNIV STRASBOURG 1, CHU STRASBOURG,DERMATOL CLIN,CNRS,DERMATOCHIM LAB, F-67091 STRASBOURG, FRANCE

[2] UNILEVER RES, ENVIRONM SAFETY LABV, SHARNBROOK MK44 1LQ, BEDS, ENGLAND

[3] KATHOLIEKE UNIV LEUVEN HOSP, DEPT DERMATOL, B-3000 LOUVAIN, BELGIUM

[4] NATL INST OCCUPAT HLTH, DEPT OCCUPAT DERMATOL, S-17184 SOLNA, SWEDEN

来源：

CONTACT DERMATITIS | 1995年 / 32卷 / 02期

关键词：

ALLERGIC CONTACT DERMATITIS; CHEMICAL BASIS; STRUCTURE-ACTIVITY RELATIONSHIPS; HAPTEN; PROHAPTEN; NUCLEOPHILE; ELECTROPHILE; SKIN METABOLISM; CROSS-SENSITIVITY; MOLECULAR MODELING;

D O I：

10.1111/j.1600-0536.1995.tb00748.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

This review concentrates on some specific aspects of the chemistry of allergic contact dermatitis. The way low molecular weight chemicals react with skin proteins to form complete antigens will be discussed and the development of molecular modelling techniques to analyse molecular recognition presented. Subsequently, how knowledge of the chemical structure can be used to estimate the allergenic activity of a molecule will be considered. This aspect includes work with qualitative and quantitative structure-activity relationships (SAR) in the field of contact allergy.

引用

页码：65 / 73

页数：9

共 55 条

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