POSITRON EMISSION TOMOGRAPHY IN SHY-DRAGER SYNDROME

被引:14
作者
BHATT, MH
SNOW, BJ
MARTIN, WRW
COOPER, S
CALNE, DB
机构
[1] UNIV BRITISH COLUMBIA,DEPT MED,DIV NEUROL,BELZBERG LAB CLIN NEUROSCI,2211 WESBROOK MALL,VANCOUVER V6T 1W5,BC,CANADA
[2] UNIV BRITISH COLUMBIA,TRIUMF,PET PROGRAM,VANCOUVER V6T 1W5,BC,CANADA
关键词
D O I
10.1002/ana.410280120
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We studied the nigrostriatal dopaminergic pathway in 3 patients with Shy‐Drager syndrome, by using positron emission tomography and [18F]6‐fluoro‐1‐dopa to determine whether their parkinsonism correlated with impaired functional integrity of the presynaptic nigrostriatal pathway. One patient had short duration of disease, mild parkinsonism, and a normal positron emission tomographic scan, suggesting pathological changes functionally distal to the nigrostriatal pathway. Two patients with longer duration of disease had more severe parkinsonism and reduced [18F]6‐fluoro‐1‐dopa uptake, suggesting impaired nigrostriatal dopaminergic function with progression of Shy‐Drager syndrome. Copyright © 1990 American Neurological Association
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页码:101 / 103
页数:3
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