INSULIN-LIKE GROWTH FACTOR-II STIMULATES MOTOR-NERVE REGENERATION

被引：131

作者：

NEAR, SL

WHALEN, LR

MILLER, JA

ISHII, DN ^{[1
]}

机构：

[1] COLORADO STATE UNIV, DEPT PHYSIOL, FT COLLINS, CO 80523 USA

[2] COLORADO STATE UNIV, DEPT ANAT & NEUROBIOL, FT COLLINS, CO 80523 USA

[3] COLORADO STATE UNIV, DEPT BIOCHEM, FT COLLINS, CO 80523 USA

[4] AMGEN INC, THOUSAND OAKS, CA 91320 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 24期

关键词：

SOMATOMEDIN; SCIATIC NERVE; AXON; NEUROTROPHIC; NEURITE;

D O I：

10.1073/pnas.89.24.11716

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Injury to mammalian motor nerves can lead to paralysis, but relatively successful regeneration may occur when conditions are favorable. Elucidation of the mechanism upholding successful regeneration is of theoretical and clinical interest. In this study, the hypothesis that insulin-like growth factor II (IGF-II) can stimulate motor nerve regeneration was tested. When IGF-II was infused continuously near a site of crush on the sciatic nerve, the distance of motor axon regeneration was increased significantly in rats. In contrast, spontaneous regeneration was inhibited when an anti-IGF-II anti-serum was infused through a "window" in the epineurium. Thus, infused IGF-II can increase, and endogenous IGFs can support, the regeneration of motor axons in lesioned nerves.

引用

页码：11716 / 11720

页数：5

共 46 条

[1] DELAYED WALLERIAN DEGENERATION IN SCIATIC-NERVES OF C57BL/OLA MICE IS ASSOCIATED WITH IMPAIRED REGENERATION OF SENSORY AXONS [J].