A LASER FLASH-PHOTOLYSIS STUDY OF DIFLUORINATED, TRIFLUORINATED AND TETRAFLUORINATED PHENYLNITRENES - IMPLICATIONS FOR PHOTOAFFINITY-LABELING

被引：69

作者：

SCHNAPP, KA ^{[1
]}

PLATZ, MS ^{[1
]}

机构：

[1] OHIO STATE UNIV,DEPT CHEM,120 W 18TH AVE,COLUMBUS,OH 43210

来源：

BIOCONJUGATE CHEMISTRY | 1993年 / 4卷 / 02期

关键词：

D O I：

10.1021/bc00020a011

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Several fluorinated aryl azides (2,6 and 2,4-difluorophenyl azide, 2,4,6-triflurorophenyl azide, and methyl 4-azido-2,3,5,6-tetrafluorobenzoate) were studied by laser flash photolysis techniques. In each case, the azides form singlet nitrenes which can be intercepted with pyridine to form ylides. This allowed determination of the rate constant for ring expansion of the singlet nitrene to the dehydroazepine and measurement of the absolute rate constants for reaction of the singlet nitrenes with typical quenchers.

引用

页码：178 / 183

页数：6

共 44 条

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