GENETIC-POLYMORPHISM OF HUMAN CYTOCHROME-P-450 (S)-MEPHENYTOIN 4-HYDROXYLASE - STUDIES WITH HUMAN AUTOANTIBODIES SUGGEST A FUNCTIONALLY ALTERED CYTOCHROME-P-450 ISOZYME AS CAUSE OF THE GENETIC DEFICIENCY

被引：48

作者：

MEIER, UT ^{[1
]}

MEYER, UA ^{[1
]}

机构：

[1] UNIV BASEL,BIOCTR,DEPT PHARMACOL,CH-4056 BASEL,SWITZERLAND

来源：

BIOCHEMISTRY | 1987年 / 26卷 / 25期

关键词：

D O I：

10.1021/bi00399a065

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：8466 / 8474

页数：9

共 50 条

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[5] BHOWN AS, 1983, METHOD ENZYMOL, V91, P450
[6] IMMUNOQUANTIFICATION OF EPOXIDE HYDROLASE AND CYTOCHROME-P-450 ISOZYMES IN FETAL AND ADULT HUMAN-LIVER MICROSOMES
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[7] CHARACTERIZATION OF A COMMON GENETIC-DEFECT OF CYTOCHROME-P-450 FUNCTION (DEBRISOQUINE-SPARTEINE TYPE POLYMORPHISM) - INCREASED MICHAELIS CONSTANT (KM) AND LOSS OF STEREOSELECTIVITY OF BUFURALOL 1'-HYDROXYLATION IN POOR METABOLIZERS
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[8] DEFECTIVE N-OXIDATION OF SPARTEINE IN MAN - NEW PHARMACOGENETIC DEFECT
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[10] MEPHENYTOIN-TYPE POLYMORPHISM OF DRUG OXIDATION - PURIFICATION AND CHARACTERIZATION OF A HUMAN-LIVER CYTOCHROME-P-450 ISOZYME CATALYZING MICROSOMAL MEPHENYTOIN HYDROXYLATION
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CATIN, T
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[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1986, 884 (03) : 435 - 447

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