CHARACTERIZATION OF A COMMON GENETIC-DEFECT OF CYTOCHROME-P-450 FUNCTION (DEBRISOQUINE-SPARTEINE TYPE POLYMORPHISM) - INCREASED MICHAELIS CONSTANT (KM) AND LOSS OF STEREOSELECTIVITY OF BUFURALOL 1'-HYDROXYLATION IN POOR METABOLIZERS

被引：77

作者：

DAYER, P ^{[1
]}

GASSER, R ^{[1
]}

GUT, J ^{[1
]}

KRONBACH, T ^{[1
]}

ROBERTZ, GM ^{[1
]}

EICHELBAUM, M ^{[1
]}

MEYER, UA ^{[1
]}

机构：

[1] UNIV BONN,DEPT MED,D-5300 BONN,FED REP GER

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1984年 / 125卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(84)80378-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：374 / 380

页数：7

共 21 条

[1]

ASLANIAN W, 1983, PHARMACOLOGIST, V25, P218

[2] PHARMACOGENETIC COVARIATION OF DEFECTIVE N-OXIDATION OF SPARTEINE AND 4-HYDROXYLATION OF DEBRISOQUINE [J].

BERTILSSON, L ;

DENGLER, HJ ;

EICHELBAUM, M ;

SCHULZ, HU .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1980, 17 (02) :153-155

[3]

BOOBIS AR, 1983, MOL PHARMACOL, V23, P474

[4]

COOPER RG, 1984, LANCET, V2, P227

[5] EVIDENCE FOR AN ENZYMATIC DEFECT IN THE 4-HYDROXYLATION OF DEBRISOQUINE BY HUMAN-LIVER [J].

DAVIES, DS ;

KAHN, GC ;

MURRAY, S ;

BRODIE, MJ ;

BOOBIS, AR .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1981, 11 (01) :89-91

[6] THE GENETIC-CONTROL OF BUFURALOL METABOLISM IN MAN [J].

DAYER, P ;

BALANT, L ;

COURVOISIER, F ;

KUPFER, A ;

KUBLI, A ;

GORGIA, A ;

FABRE, J .

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 1982, 7 (01) :73-77

[7]

DAYER P, 1984, XENOBIOTICA S1, V14, P100

[8]

EICHELBAUM M, 1982, CLIN PHARMACOKINET, V7, P1, DOI 10.2165/00003088-198207010-00001

[9] A FAMILY AND POPULATION STUDY OF THE GENETIC-POLYMORPHISM OF DEBRISOQUINE OXIDATION IN A WHITE BRITISH-POPULATION [J].

EVANS, DAP ;

MAHGOUB, A ;

SLOAN, TP ;

IDLE, JR ;

SMITH, RL .

JOURNAL OF MEDICAL GENETICS, 1980, 17 (02) :102-105

[10] KINETICS AND METABOLISM OF (+)-BUFURALOL, (-)-BUFURALOL AND (+/-)-BUFURALOL [J].

FRANCIS, RJ ;

EAST, PB ;

LARMAN, J .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1982, 23 (06) :529-533

← 1 2 3 →