DETECTION OF SERUM ANTIBODIES TO RETROVIRAL PROTEINS IN PATIENTS WITH PRIMARY SJOGRENS-SYNDROME (AUTOIMMUNE EXOCRINOPATHY)

被引:214
作者
TALAL, N
DAUPHINEE, MJ
DANG, H
ALEXANDER, SS
HART, DJ
GARRY, RF
机构
[1] AUDIE L MURPHY MEM VET ADM MED CTR,SAN ANTONIO,TX 78284
[2] TULANE UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL,NEW ORLEANS,LA 70112
[3] BIOTECH RES LABS INC,ROCKVILLE,MD
来源
ARTHRITIS AND RHEUMATISM | 1990年 / 33卷 / 06期
关键词
D O I
10.1002/art.1780330603
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Primary Sjögren's syndrome (SS) is considered a benign autoimmune disease; it is characterized by lymphoid infiltration of salivary and lacrimal glands, often accompanied by the presence of serum autoantibodies, particularly anti‐Ro (SS‐A) and anti‐La (SS‐B). There are important immunologic similarities between primary SS and acquired immunodeficiency syndrome. To investigate for a possible immune response to retroviral proteins in primary SS, we performed immunoblotting against human immunodeficiency virus‐1 (HIV‐1) proteins using sera from 47 patients with primary SS. Moderate‐to‐strong reactivity, suggesting the presence of serum antibodies, was found in 14 patients (30%). Of 120 normal subjects, only 1 showed moderate positivity. All 14 positive SS sera reacted against p24 (gag) but failed to react against gp41 or gp120 (env). This response did not reflect hypergammaglobulinemia since immunoglobulin concentrations among the 29 SS patients studied were the same in sera that contained and sera that did not contain anti‐gag reactivity. Two sera also reacted against p17 gag. Four reacted against HIV‐2 core proteins, but none reacted with core proteins of human T lymphotropic virus‐I. Only 1 of the 14 sera reacted against Ro (SS‐A), and 1 other reacted against La (SS‐B). These results identify a subset of SS patients characterized by 1) the presence of serum antibodies to HIV‐1 group‐specific, but not type‐specific, proteins, and 2) the relative absence of anti‐Ro (SS‐A) and anti‐La (SS‐B) autoantibodies. In this latter respect, these SS patients constitute a subpopulation that resembles patients with HIV‐induced SS‐like disease. Copyright © 1990 American College of Rheumatology
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页码:774 / 781
页数:8
相关论文
共 33 条
[11]   LY-1 B-CELLS - FUNCTIONALLY DISTINCT LYMPHOCYTES THAT SECRETE IGM AUTOANTIBODIES [J].
HAYAKAWA, K ;
HARDY, RR ;
HONDA, M ;
HERZENBERG, LA ;
STEINBERG, AD ;
HERZENBERG, LA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (08) :2494-2498
[12]  
HERMANN M, 1989, MOL CELLULAR MECHANI
[13]   INVESTIGATION OF ATYPICAL WESTERN BLOT (IMMUNOBLOT) REACTIVITY INVOLVING CORE PROTEINS OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 [J].
JOSEPHSON, SL ;
SWACK, NS ;
RAMIREZ, MT ;
HAUSLER, WJ .
JOURNAL OF CLINICAL MICROBIOLOGY, 1989, 27 (05) :932-937
[14]   MULTIPLE-SCLEROSIS AND HUMAN T-CELL LYMPHOTROPIC RETROVIRUSES [J].
KOPROWSKI, H ;
DEFREITAS, EC ;
HARPER, ME ;
SANDBERGWOLLHEIM, M ;
SHEREMATA, WA ;
ROBERTGUROFF, M ;
SAXINGER, CW ;
FEINBERG, MB ;
WONGSTAAL, F ;
GALLO, RC .
NATURE, 1985, 318 (6042) :154-160
[15]  
LESLIE PN, 1987, LANCET, V1, P632
[16]   HIV-1 INFECTED T-CELLS SHOW A SELECTIVE SIGNALING DEFECT AFTER PERTURBATION OF CD3/ANTIGEN RECEPTOR [J].
LINETTE, GP ;
HARTZMAN, RJ ;
LEDBETTER, JA ;
JUNE, CH .
SCIENCE, 1988, 241 (4865) :573-576
[17]   DETERMINATION OF AN EPITOPE OF THE DIFFUSE SYSTEMIC-SCLEROSIS MARKER ANTIGEN DNA TOPOISOMERASE-I - SEQUENCE SIMILARITY WITH RETROVIRAL P30GAG PROTEIN SUGGESTS A POSSIBLE CAUSE FOR AUTOIMMUNITY IN SYSTEMIC-SCLEROSIS [J].
MAUL, GG ;
JIMENEZ, SA ;
RIGGS, E ;
ZIEMNICKAKOTULA, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (21) :8492-8496
[18]  
MOODY DJ, 1988, AUTOIMMUNITY HIV INF, V141
[19]   HIGH IGM ANTIBODY TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-I IN SYSTEMIC LUPUS-ERYTHEMATOSUS [J].
PHILLIPS, PE ;
JOHNSTON, SL ;
RUNGE, LA ;
MOORE, JL ;
POIESZ, BJ .
JOURNAL OF CLINICAL IMMUNOLOGY, 1986, 6 (03) :234-241
[20]   A RHEUMATOID-ARTHRITIS B-CELL SUBSET EXPRESSES A PHENOTYPE SIMILAR TO THAT IN CHRONIC LYMPHOCYTIC-LEUKEMIA [J].
PLATERZYBERK, C ;
MAINI, RN ;
LAM, K ;
KENNEDY, TD ;
JANOSSY, G .
ARTHRITIS AND RHEUMATISM, 1985, 28 (09) :971-976