CONSISTENT CHANGES IN THE CIRCADIAN-RHYTHMS OF BLOOD-PRESSURE AND ATRIAL-NATRIURETIC-PEPTIDE IN CONGESTIVE-HEART-FAILURE

被引：29

作者：

PORTALUPPI, F

MONTANARI, L

FERLINI, M

VERGNANI, L

DAMBROSI, A

CAVALLINI, AR

BAGNI, B

UBERTI, ED

机构：

[1] Internal Medicine and Endocrinology Section, University of Ferrara, Ferrara

[2] Institute of Internal Medicine, University of Ferrara, Ferrara

[3] Nuclear Medicine Service, St. Anna Hospital, Ferrara

来源：

CHRONOBIOLOGY INTERNATIONAL | 1991年 / 8卷 / 05期

关键词：

ATRIAL NATRIURETIC PEPTIDE; BLOOD PRESSURE; HEART RATE; CONGESTIVE HEART FAILURE; CIRCADIAN RHYTHMS;

D O I：

10.3109/07420529109059178

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We demonstrated in previous works that the circadian rhythms of blood pressure (BP) and atrial natriuretic peptide (ANP) are antiphasic in normal subjects and in essential hypertension. The aim of the present study was to assess the circadian rhythms of BP and ANP in 20 patients with stable congestive heart failure (CHF), divided into two groups of 10 according to their New York Heart Association functional class. A matched control group of 10 normal volunteers was also studied. Noninvasive BP monitoring at 15-min intervals was performed for 24 h. Peripheral blood samples were also obtained at 4-h intervals starting from 08:00 h. The mean (+/- SEM) circadian mesors of ANP plasma levels were 13.4 +/- 1.7 pmol/L in the control group, 28.6 +/- 2.4 pmol/L in the group of 10 patients in class II, and 81.5 +/- 12 pmol/L in the group of 10 patients in class III-IV. In normal subjects, plasma ANP concentration was highest at 04:00 h (21.5 +/- 2.7 pmol/L) and lowest at 16:00 h (8.8 +/- 2.4 pmol/L; p < 0.01). Both groups of patients with CHF showed no significant circadian change in the plasma levels of ANP and also a significantly blunted circadian rhythm of BP. Cosinor analysis confirmed the loss of the circadian rhythms of ANP and BP in CHF patients. Our findings support the existence of a causal relationship between the circadian rhythms of ANP and BP.

引用

页码：432 / 439

页数：8

共 49 条

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