MAST-CELL ACTIVATION INDUCES P-SELECTIN-DEPENDENT LEUKOCYTE ROLLING AND ADHESION IN POSTCAPILLARY VENULES IN-VIVO

被引：54

作者：

THORLACIUS, H ^{[1
]}

RAUD, J ^{[1
]}

ROSENGRENBEEZLEY, S ^{[1
]}

FORREST, MJ ^{[1
]}

HEDQVIST, P ^{[1
]}

LINDBOM, L ^{[1
]}

机构：

[1] CYTEL CORP,SAN DIEGO,CA 92121

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 203卷 / 02期

关键词：

D O I：

10.1006/bbrc.1994.2287

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As studied by intravital microscopy, local challenge with the mast cell secretagogue compound 48/80 was found to increase the leukocyte rolling fraction, decrease rolling velocity and induce firm leukocyte adhesion in postcapillary venules of the rat mesentery. These effects of compound 48/80 were inhibited by a monoclonal anti-P-selectin antibody, but not by combined treatment with H-1 and H-2 histamine-receptor antagonists. Moreover, the response to compound 48/80 was not mimicked by exogenous histamine or 5-hydroxytryptamine (5-HT). These novel findings indicate that mediator(s) other than histamine and 5-HT evoke P-selectin-dependent leukocyte rolling and thereby promote firm leukocyte adhesion in mast cell-dependent inflammation. (C) 1994 Academic Press, Inc.

引用

页码：1043 / 1049

页数：7

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