MAST-CELL ACTIVATION INDUCES P-SELECTIN-DEPENDENT LEUKOCYTE ROLLING AND ADHESION IN POSTCAPILLARY VENULES IN-VIVO

被引:54
作者
THORLACIUS, H [1 ]
RAUD, J [1 ]
ROSENGRENBEEZLEY, S [1 ]
FORREST, MJ [1 ]
HEDQVIST, P [1 ]
LINDBOM, L [1 ]
机构
[1] CYTEL CORP,SAN DIEGO,CA 92121
关键词
D O I
10.1006/bbrc.1994.2287
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
As studied by intravital microscopy, local challenge with the mast cell secretagogue compound 48/80 was found to increase the leukocyte rolling fraction, decrease rolling velocity and induce firm leukocyte adhesion in postcapillary venules of the rat mesentery. These effects of compound 48/80 were inhibited by a monoclonal anti-P-selectin antibody, but not by combined treatment with H-1 and H-2 histamine-receptor antagonists. Moreover, the response to compound 48/80 was not mimicked by exogenous histamine or 5-hydroxytryptamine (5-HT). These novel findings indicate that mediator(s) other than histamine and 5-HT evoke P-selectin-dependent leukocyte rolling and thereby promote firm leukocyte adhesion in mast cell-dependent inflammation. (C) 1994 Academic Press, Inc.
引用
收藏
页码:1043 / 1049
页数:7
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