METABOLIC BIOMARKERS OF PARKINSONS-DISEASE

被引：14

作者：

WILLIAMS, A ^{[1
]}

STURMAN, S ^{[1
]}

STEVENTON, G ^{[1
]}

WARING, R ^{[1
]}

机构：

[1] UNIV BIRMINGHAM,DEPT BIOCHEM,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

来源：

ACTA NEUROLOGICA SCANDINAVICA | 1991年 / 84卷

关键词：

XENOBIOTIC; MONOAMINE OXIDASE-B; CYSTEINE; S-METHYLATION; N-METHYLATION;

D O I：

10.1111/j.1600-0404.1991.tb05015.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Enzymic systems involved with metabolism of foreign chemicals, xenobiotics, have been studied in Parkinson's disease. Enzymes involved with sulphur oxidation and methylation are under-active. Cysteine levels are high and sulphate levels low. Differences in the activity of the enzyme monoamine oxidase-B are evident. Pathways involved with N-methylation of pyridines are different from controls leading to a rise in potentially toxic N-methylated derivatives.

引用

页码：19 / 23

页数：5

共 18 条

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