LIPASE-CATALYZED KINETIC RESOLUTION OF PHENYLCYCLOHEXANONE OXIME ESTERS

被引：13

作者：

MURAKATA, M ^{[1
]}

IMAI, M ^{[1
]}

TAMURA, M ^{[1
]}

HOSHINO, O ^{[1
]}

机构：

[1] SCI UNIV TOKYO,FAC PHARMACEUT SCI,SHINJUKU KU,TOKYO 162,JAPAN

来源：

TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 10期

关键词：

D O I：

10.1016/S0957-4166(00)86277-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Formation of optically active alpha or gamma-phenylcyclohexanone oximes (2a and 2b, c) and their esters (1a and 3b, c) by lipase mediated transesterification of the corresponding racemic esters is described. Furthermore, 2(S)-phenyl and 2,2-dimethyl-4(R)-phenylcyclohexanones (4 and 5) were prepared without any racemization by treatment with dimethyldioxirane in acetone or sodium hydrogen sulfite in refluxing aqueous ethanol.

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页码：2019 / 2024

页数：6

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