COMPLEX FORMATION BETWEEN LYSYL TRANSFER RNA SYNTHETASE AND POLYURIDYLIC ACID

被引：21

作者：

LETENDRE, CH

HUMPHREYS, JM

GRUNBERGMANAGO, M

机构：

[1] Institut de Biologie Physico-chimique, Paris

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1969年 / 186卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0005-2787(69)90489-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has been found that poly U is a competitive inhibitor of tRNA for its charging by purified lysyl-tRNA synthetase from yeast, while it is not inhibitory for yeast phenylalanyl-tRNA synthetase. Lysyl-tRNA synthetase can be shown to form a complex with its specific tRNA and with poly U. Poly U can be largely displaced from the enzyme by the addition of tRNA at a ratio ( tRNA poly U) where the charging reaction is hardly inhibited. Poly A does not form a complex with the enzyme and does not inhibit the attachment of lysine to tRNA. © 1969.

引用

页码：46 / +

页数：1

共 39 条

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