ENRICHED ENVIRONMENT PRIMES FOREBRAIN CHOLINE-ACETYLTRANSFERASE ACTIVITY TO RESPOND TO LEARNING-EXPERIENCE

被引：64

作者：

PARK, GAS

PAPPAS, BA

MURTHA, SM

ALLY, A

机构：

[1] CARLETON UNIV,DEPT PSYCHOL,BEHAV MED & PHARMACOL UNIT,OTTAWA K1S 5B6,ONTARIO,CANADA

[2] NATL RES COUNCIL CANADA,OTTAWA K1A 0R6,ONTARIO,CANADA

来源：

NEUROSCIENCE LETTERS | 1992年 / 143卷 / 1-2期

基金：

加拿大自然科学与工程研究理事会;

关键词：

ENRICHMENT; MAZE LEARNING; CHOLINE ACETYLTRANSFERASE; ACETYLCHOLINE;

D O I：

10.1016/0304-3940(92)90278-F

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Weanling rats were raised in an enriched or an impoverished environment. The enriched rats subsequently learned the Morris water maze faster than their impoverished counterparts. The enriched rats, both maze-trained and untrained, showed higher choline acetyltransferase (ChAT) activity in the caudate than did the impoverished, untrained rats. Maze training increased caudate ChAT in impoverished rats. Enriched but not impoverished rats showed increased hippocampal and anterior cortical ChAT activity after maze training. Thus, enrichment causes a long-lasting increase in caudate acetylcholine (Ach) synthesis and it also primes cortex and hippocampus to respond to a training experience with increased Ach synthesis.

引用

页码：259 / 262

页数：4

共 18 条

[1] MAZE TRAINING ALTERS BRAIN WEIGHTS AND CORTICAL RNA-DNA RATIOS [J].