ISOLATION OF LANOSTANE-TYPE TRITERPENE ACIDS HAVING AN ACETOXYL GROUP FROM SCLEROTIA OF PORIA-COCOS

被引：100

作者：

TAI, T

SHINGU, T

KIKUCHI, T

TEZUKA, Y

AKAHORI, A

机构：

[1] KOBE GAKUIN UNIV,FAC PHARMACEUT SCI,NISHI KU,KOBE 65121,JAPAN

[2] TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU,TOYAMA 93001,JAPAN

来源：

PHYTOCHEMISTRY | 1995年 / 40卷 / 01期

关键词：

PORIA COCOS; POLYPORACEAE; 3-O-ACETYL-16-ALPHA-HYDROXYTRAMETENOLIC ACID; 3-O-ACETYL-16-ALPHA-HYDROXYDEHYDROTRAMETENOLIC ACID; 3-EPIDEHYDROPACHYMIC ACID; DEHYDROPACHYMIC ACID; PACHYMIC ACID; N-CHLOROMETHYLPHTHALIMIDE; HPLC;

D O I：

10.1016/0031-9422(95)00182-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The separation of lanostane-type triterpene acids carrying an acetoxyl group from sclerotia of Poria cocos (hoelen) was effectively achieved by means of preparative HPLC of the phthalimidomethyl esters followed by selective hydrolysis of the phthalimidomethyl ester groupings. By this method, three new triterpene acids were isolated together with pachymic and dehydropachymic acids, which are characteristic compounds of hoelen. The structures of three new compounds were determined to be 3-o-acetyl-16 alpha-hydroxytrametenolic acid, 3-o-acetyl-16 alpha-hydroxydehydrotrametenolic acid, and 3-epidehydropachymic acid, respectively, based on spectroscopic evidence.

引用

页码：225 / 231

页数：7

共 5 条

[1]

C-13 NMR-STUDIES OF THE TRITERPENE 3-ALPHA-HYDROXYLUP-20(29)-EN-23,28-DIOIC ACID AND SOME DERIVATIVES [J].