SELECTIVITY IN THE DESIGN OF THE TOTAL SYNTHESIS OF NATURAL-PRODUCTS

被引：37

作者：

TROST, BM

机构：

[1] Department of Chemistry, University of Wisconsin, Madison, Wisconsin

来源：

PURE AND APPLIED CHEMISTRY | 1979年 / 51卷 / 04期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1351/pac197951040787

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of complex natural products requires the development of selective methods to create molecular architecture. The utilization of palladium complexes as templates to achieve such selectivity is discussed in terms of effecting substitutions at allylic positions. The chemo-, regio-, and stereocontrol exhibited by such reactions is outlined. The facilitation of synthetic strategy is considered. Synthetic targets include steroids, macrolides, amino acids, and alkaloids and the total synthesis of representatives of each of these classes is presented. © IUPAC

引用

页码：787 / 800

页数：14

共 19 条

[11] STEREOCONTROLLED SYNTHESIS OF ECDYSONE SIDE-CHAIN VIA ORGANOPALLADIUM CHEMISTRY
TROST, BM
MATSUMURA, Y
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1977, 42 (11) : 2036 - 2038
[12] ALLYLIC ALKYLATION - PREPARATION OF PI-ALLYLPALLADIUM COMPLEXES FROM OLEFINS
TROST, BM
STREGE, PE
WEBER, L
FULLERTON, TJ
DIETSCHE, TJ
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1978, 100 (11) : 3407 - 3415
[13] ALLYLIC SUBSTITUTIONS WITH RETENTION OF STEREOCHEMISTRY
TROST, BM
VERHOEVEN, TR
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1976, 41 (19) : 3215 - 3216
[14] TOTAL SYNTHESIS OF RACEMIC AND OPTICALLY-ACTIVE IBOGAMINE - UTILIZATION AND MECHANISM OF A NEW SILVER ION ASSISTED PALLADIUM CATALYZED CYCLIZATION
TROST, BM
GODLESKI, SA
GENET, JP
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1978, 100 (12) : 3930 - 3931
[15] TROST BM, 1976, TETRAHEDRON LETT, P3477
[16] PALLADIUM CATALYZED CYCLIZATIONS TO ALKALOID SKELETONS - FACILE SYNTHESIS OF DESETHYLIBOGAMINE
TROST, BM
GENET, JP
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1976, 98 (26) : 8516 - 8517
[17] ALLYLIC ALKYLATION - NATURE OF NUCLEOPHILE AND APPLICATION TO PRENYLATION
TROST, BM
WEBER, L
STREGE, P
FULLERTON, TJ
DIETSCHE, TJ
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1978, 100 (11) : 3426 - 3435
[18] ALLYLIC ALKYLATION - NUCLEOPHILIC-ATTACK ON PI-ALLYLPALLADIUM COMPLEXES
TROST, BM
WEBER, L
STREGE, PE
FULLERTON, TJ
DIETSCHE, TJ
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1978, 100 (11) : 3416 - 3426
[19] TROST BM, UNPUBLISHED

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