DETECTION AND CHARACTERIZATION OF MUMPS VIRUS-V PROTEIN

被引:45
作者
TAKEUCHI, K [1 ]
TANABAYASHI, K [1 ]
HISHIYAMA, M [1 ]
YAMADA, YK [1 ]
YAMADA, A [1 ]
SUGIURA, A [1 ]
机构
[1] NATL INST HLTH,DEPT VET SCI,MUSASHI MURAYAMA,TOKYO 19012,JAPAN
关键词
D O I
10.1016/0042-6822(90)90400-L
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
By cDNA cloning, DNA sequencing, and RNAse mapping analyses two distinct mRNA species were shown to be transcribed from the mumps virus P gene; one faithful and the other edited copies. The former was found to direct the synthesis of the V protein (25K), while the latter, after the addition of two nontemplated G residues, was found to direct the synthesis of the P protein (40K-42K). The carboxy terminal of the V protein contained a cysteine-rich region which was similar but not identical to the metal binding domain motif found in several nucleic acid binding proteins. The V protein was detected not only in mumps virus-infected cells but also in the virions by antiserum raised against a synthetic peptide. © 1990.
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收藏
页码:247 / 253
页数:7
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