PRIMARY CORONARY VASODILATION ASSOCIATED WITH PAUSES IN HEART RHYTHM DURING SLEEP

被引:24
作者
DICKERSON, LW [1 ]
HUANG, AH [1 ]
NEARING, BD [1 ]
VERRIER, RL [1 ]
机构
[1] GEORGETOWN UNIV,SCH MED,DEPT PHARMACOL,3900 RESERVOIR RD NW,WASHINGTON,DC 20007
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1993年 / 264卷 / 01期
关键词
VAGUS NERVE; SLOW-WAVE SLEEP; RAPID-EYE-MOVEMENT SLEEP; AROUSAL; ARRHYTHMIAS; APNEA; CORONARY BLOOD FLOW; NOCTURNAL ANGINA;
D O I
10.1152/ajpregu.1993.264.1.R186
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
We observed 162 epsiodes of pause in heart rhythm in chronically instrumented dogs primarily during transitions from deep slow-wave sleep to other stages of sleep. These pauses lasted 1.1-8.0 s and were followed by increases in coronary blood flow (CBF) averaging 30% and ranging up to 84%. The postpause surges in CBF do not appear to be mediated by local metabolic factors because the flow surges occurred without significant changes in the heart rate x systolic blood pressure (HRxSBP) product, a standard index of cardiac metabolic activity. Enhanced vagal tone is suggested by the background of marked respiratory sinus arrhythmia, low average heart rates, and the hallmark event, the pause in heart rhythm. In a series of experiments in a-chloralose-anesthetized dogs, we demonstrated that direct vagus nerve stimulation can induce both the pause in heart rhythm and the postpause increase in CBF in a pattern similar to that observed during sleep. This response was markedly attenuated after pericoronary denervation. These observations provide suggestive evidence but not definitive proof that enhanced vagal activity may be involved in the increase in CBF after spontaneous pauses in heart rhythm during sleep.
引用
收藏
页码:R186 / R196
页数:11
相关论文
共 37 条
  • [21] HILTON SM, 1982, J EXP BIOL, V100, P159
  • [22] EFFECT OF SINOAORTIC DENERVATION ON AROUSAL RESPONSES TO HYPOTENSION IN NEWBORN LAMBS
    HORNE, RSC
    BERGER, PJ
    BOWES, G
    WALKER, AM
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (02): : H434 - H440
  • [23] DIFFERENTIAL-EFFECTS OF SLEEP STAGE ON CORONARY HEMODYNAMIC FUNCTION
    KIRBY, DA
    VERRIER, RL
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (05): : H1378 - H1383
  • [24] KIRBY DA, 1989, PHYSIOL BEHAV, V45, P1
  • [25] Lim RKS, 1960, STEREOTAXIC ATLAS DO
  • [26] BASELINE SLEEP-WAKE PATTERNS IN POINTER DOG
    LUCAS, EA
    POWELL, EW
    MURPHREE, OD
    [J]. PHYSIOLOGY & BEHAVIOR, 1977, 19 (02) : 285 - 291
  • [27] PARADOXICAL VASOCONSTRICTION INDUCED BY ACETYLCHOLINE IN ATHEROSCLEROTIC CORONARY-ARTERIES
    LUDMER, PL
    SELWYN, AP
    SHOOK, TL
    WAYNE, RR
    MUDGE, GH
    ALEXANDER, RW
    GANZ, P
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1986, 315 (17) : 1046 - 1051
  • [28] ASSOCIATION OF NOCTURNAL ANGINA PECTORIS WITH DREAMING
    NOWLIN, JB
    TROYER, WG
    COLLINS, WS
    SILVERMAN, G
    NICHOLS, CR
    MCINTOSH, HD
    ESTES, EH
    BOGDONOFF, MD
    [J]. ANNALS OF INTERNAL MEDICINE, 1965, 63 (06) : 1040 - +
  • [29] Parmeggiani PL., 1990, CENTRAL REGULATION A, P367
  • [30] RAETZ S, 1992, SLEEP, V14, P526