INTRASTRIATAL INFUSIONS OF ASCORBATE ANTAGONIZE THE BEHAVIORAL-RESPONSE TO AMPHETAMINE

被引：28

作者：

WHITE, LK ^{[1
]}

MAURER, M ^{[1
]}

KRAFT, ME ^{[1
]}

OH, CJ ^{[1
]}

REBEC, GV ^{[1
]}

机构：

[1] INDIANA UNIV,DEPT PSYCHOL,PROGRAM NEURAL SCI,BLOOMINGTON,IN 47405

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1990年 / 36卷 / 03期

关键词：

Amphetamine; Ascorbate; Haloperidol; Intrastriatal infusions;

D O I：

10.1016/0091-3057(90)90245-D

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Compared to saline, bilateral infusions of ascorbate (AA) into the neostriatum of freely moving rats attenuated rearing, head bobbing, and sniffing at various times after systemic amphetamine administration. Comparable AA infusions into overlying cerebral cortex failed to alter the amphetamine behavioral response. Intrastriatal AA also enhanced the ability of haloperidol to antagonize amphetamine-induced forepaw shuffling and locomotion. Voltammetric measurements in separate animals revealed a linear increase in neostriatal AA that remained within reasonable physiological limits over the course of the AA infusion. Thus, endogenous AA may modulate behavior via mechanisms intrinsic to the neostriatum. © 1990.

引用

页码：485 / 489

页数：5

共 32 条

[1]

Adams R. N., 1976, ANAL CHEM, V48, p1128A

[2] CORTICOSTRIATAL AND THALAMIC REGULATION OF AMPHETAMINE-INDUCED ASCORBATE RELEASE IN THE NEOSTRIATUM [J].

BASSETOMUSK, A ;

REBEC, GV .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1990, 35 (01) :55-60

[3] RAPID CHANGES IN STRIATAL ASCORBATE IN RESPONSE TO TAIL-PINCH MONITORED BY CONSTANT POTENTIAL VOLTAMMETRY [J].

BOUTELLE, MG ;

SVENSSON, L ;

FILLENZ, M .

NEUROSCIENCE, 1989, 30 (01) :11-17

[4]

DORRIS RL, 1987, P SOC EXP BIOL MED, V186, P13

[5] SIMULTANEOUS ELECTROCHEMICAL AND UNIT RECORDING MEASUREMENTS - CHARACTERIZATION OF THE EFFECTS OF D-AMPHETAMINE AND ASCORBIC-ACID ON NEOSTRIATAL NEURONS [J].

EWING, AG ;

ALLOWAY, KD ;

CURTIS, SD ;

DAYTON, MA ;

WIGHTMAN, RM ;

REBEC, GV .

BRAIN RESEARCH, 1983, 261 (01) :101-108

[6] MODULATION OF NEOSTRIATAL ACTIVITY BY IONTOPHORESIS OF ASCORBIC-ACID [J].

GARDINER, TW ;

ARMSTRONGJAMES, M ;

CAAN, AW ;

WIGHTMAN, RM ;

REBEC, GV .

BRAIN RESEARCH, 1985, 344 (01) :181-185

[7] VOLTAMMETRY IN THE STRIATUM OF CHRONIC FREELY MOVING RATS - DETECTION OF CATECHOLS AND ASCORBIC-ACID [J].

GONON, F ;

BUDA, M ;

CESPUGLIO, R ;

JOUVET, M ;

PUJOL, JF .

BRAIN RESEARCH, 1981, 223 (01) :69-80

[8] ELECTROCHEMICAL TREATMENT OF PYROLYTIC CARBON-FIBER ELECTRODES [J].

GONON, FG ;

FOMBARLET, CM ;

BUDA, MJ ;

PUJOL, JF .

ANALYTICAL CHEMISTRY, 1981, 53 (09) :1386-1389

[9] THE ORIGIN OF CIRCADIAN AND AMPHETAMINE-INDUCED CHANGES IN THE EXTRACELLULAR CONCENTRATION OF BRAIN ASCORBATE [J].

GRUNEWALD, RA ;

ONEILL, RD ;

FILLENZ, M ;

ALBERY, WJ .

NEUROCHEMISTRY INTERNATIONAL, 1983, 5 (06) :773-778

[10] ASCORBIC-ACID COULD BE HAZARDOUS TO YOUR EXPERIMENTS - A COMMENTARY ON DOPAMINE RECEPTOR-BINDING STUDIES WITH SPECULATION ON A ROLE FOR ASCORBIC-ACID IN NEURONAL FUNCTION [J].

HADJICONSTANTINOU, M ;

NEFF, NH .

NEUROPHARMACOLOGY, 1983, 22 (08) :939-943

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