MODIFIED STARCHES AS HYDROPHILIC MATRICES FOR CONTROLLED ORAL DELIVERY .3. EVALUATION OF SUSTAINED-RELEASE THEOPHYLLINE FORMULATIONS BASED ON THERMAL MODIFIED STARCH MATRICES IN DOGS

被引：16

作者：

HERMAN, J ^{[1
]}

REMON, JP ^{[1
]}

机构：

[1] STATE UNIV GHENT,PHARMACEUT TECHNOL LAB,B-9000 GHENT,BELGIUM

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1990年 / 63卷 / 03期

关键词：

Bioavailability; Modified starch; Sustained-release dosage form; Theophylline;

D O I：

10.1016/0378-5173(90)90125-N

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The sustained-release of theophylline from several thermal modified starch matrices was evaluated in dogs in comparison to the commercial formulation Theodur 300. Matrices formulated with starches containing 70% amylose revealed a minor shift in tmax in comparison with a conventional tablet. The matrices containing amylose free starches showed tmax values of ±4 h. Starch matrices containing 25% amylose demonstrated a good sustained-release performance, comparable to Theodur 300. The influence of the drug/starch ratio was investigated on two types of starches containing 25% amylose: drum dried corn starch and extruded corn starch. A starch/drug ratio between 50 50 and 70 30 showed no significant influence on the biopharmaceutical parameters investigated. © 1990.

引用

页码：201 / 205

页数：5

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