EFFECT OF SELENIUM AND VITAMIN-E ON THE DEVELOPMENT OF EXPERIMENTAL ATHEROSCLEROSIS IN RABBITS

被引：155

作者：

WOJCICKI, J ^{[1
]}

ROZEWICKA, L ^{[1
]}

BARCEWWISZNIEWSKA, B ^{[1
]}

SAMOCHOWIEC, L ^{[1
]}

JUZWIAK, S ^{[1
]}

KADLUBOWSKA, D ^{[1
]}

TUSTANOWSKI, S ^{[1
]}

JUZYSZYN, Z ^{[1
]}

机构：

[1] POMERANIAN MED ACAD,DEPT RADIOISOTOPES,PL-70111 SZCZECIN,POLAND

来源：

ATHEROSCLEROSIS | 1991年 / 87卷 / 01期

关键词：

EXPERIMENTAL ATHEROSCLEROSIS; HIGH-FAT DIET; RABBITS; SELENIUM; VITAMIN-E;

D O I：

10.1016/0021-9150(91)90227-T

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Male mongrel rabbits, divided into 5 groups (1) controls, (2) animals receiving a high-fat diet (HFD) containing cholesterol and coconut oil, (3) HFD + selenium, (4) HFD + vitamin E, (5) HFD + selenium + vitamin E, were treated for 12 weeks. In the groups receiving selenium and/or vitamin E, the elevation of serum total lipids, beta-lipoproteins, total cholesterol and triglyceride was markedly suppressed. HDL cholesterol in these groups of animals was increased. The cytochrome P-450 content in liver microsomes was increased, and the concentration of malondialdehyde in the blood plasma of rabbits was significantly decreased, while thyroid hormones (T4, T3), cortisol and insulin level were increased. Surface area of the lipid deposits at 12 weeks measured planimetrically averaged 76% in HFD-fed animals but only 28% in selenium + vitamin E treated rabbits. The important finding of this study is that combination of selenium and vitamin E, results in an intensified effect on the improvement of metabolic processes and on the reduction of atherosclerotic plaque formation.

引用

页码：9 / 16

页数：8

共 34 条

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