ROLE OF DNA-PLOIDY AND ERB-B2 ONCOGENE EXPRESSION IN THE PROGNOSIS OF ENDOMETRIAL CARCINOMA

被引：2

作者：

FERRARA, F ^{[1
]}

DESANTIS, L ^{[1
]}

MANGILI, F ^{[1
]}

SASSI, I ^{[1
]}

LUCHINI, S ^{[1
]}

MANDELLI, C ^{[1
]}

SANTAMBROGIO, G ^{[1
]}

CANTABONI, A ^{[1
]}

机构：

[1] UNIV MILAN, IRCCS H SAN RAFFAELE, CATTEDRA ANAT & ISTOL PATOL, MILAN, ITALY

来源：

PATHOLOGY RESEARCH AND PRACTICE | 1994年 / 190卷 / 11期

关键词：

ENDOMETRIAL CARCINOMA; DNA PLOIDY; IMMUNOHISTOCHEMISTRY; ONCOGENE; ERB-B2; OVEREXPRESSION;

D O I：

10.1016/S0344-0338(11)80899-X

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Seventy-three patients with endometrial carcinoma have been retrospectively evaluated in this paper Stage, grade, depth of myometrial invasion, flow cytometric DNA ploidy and ERB-B2 oncogene expression by immunohistochemical method have been analyzed on paraffin embedded tissue. Results showed the existence of a significant correlation between stage and grade of neoplasia and between DNA ploidy and course of disease; it has been observed that patients with aneuploid tumor tend to have a shorter time before relapse of disease. No significant correlation between depth of myometrial invasion and survival was found. Besides, it has been shown that tumours with ERB-B2 oncogene hyperexpression seem to have a more aggressive evolution.

引用

页码：1039 / 1043

页数：5

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