ROLE OF DNA-PLOIDY AND ERB-B2 ONCOGENE EXPRESSION IN THE PROGNOSIS OF ENDOMETRIAL CARCINOMA

被引：2

作者：

FERRARA, F ^{[1
]}

DESANTIS, L ^{[1
]}

MANGILI, F ^{[1
]}

SASSI, I ^{[1
]}

LUCHINI, S ^{[1
]}

MANDELLI, C ^{[1
]}

SANTAMBROGIO, G ^{[1
]}

CANTABONI, A ^{[1
]}

机构：

[1] UNIV MILAN, IRCCS H SAN RAFFAELE, CATTEDRA ANAT & ISTOL PATOL, MILAN, ITALY

来源：

PATHOLOGY RESEARCH AND PRACTICE | 1994年 / 190卷 / 11期

关键词：

ENDOMETRIAL CARCINOMA; DNA PLOIDY; IMMUNOHISTOCHEMISTRY; ONCOGENE; ERB-B2; OVEREXPRESSION;

D O I：

10.1016/S0344-0338(11)80899-X

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Seventy-three patients with endometrial carcinoma have been retrospectively evaluated in this paper Stage, grade, depth of myometrial invasion, flow cytometric DNA ploidy and ERB-B2 oncogene expression by immunohistochemical method have been analyzed on paraffin embedded tissue. Results showed the existence of a significant correlation between stage and grade of neoplasia and between DNA ploidy and course of disease; it has been observed that patients with aneuploid tumor tend to have a shorter time before relapse of disease. No significant correlation between depth of myometrial invasion and survival was found. Besides, it has been shown that tumours with ERB-B2 oncogene hyperexpression seem to have a more aggressive evolution.

引用

页码：1039 / 1043

页数：5

共 30 条

[11] CONVENTION ON NOMENCLATURE FOR DNA CYTOMETRY [J].

HIDDEMANN, W ;

SCHUMANN, J ;

ANDREEFF, M ;

BARLOGIE, B ;

HERMAN, CJ ;

LEIF, RC ;

MAYALL, BH ;

MURPHY, RF ;

SANDBERG, AA .

CYTOMETRY, 1984, 5 (05) :445-446

[12] FLOW CYTOMETRIC DEOXYRIBONUCLEIC-ACID INDEX - A PROGNOSTIC FACTOR IN ENDOMETRIAL CARCINOMA [J].

IVERSEN, OE .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1986, 155 (04) :770-776

[13]

JACOBSEN M, 1991, APMIS, V99, P107

[14]

JOENSUU H, 1988, AM J PATHOL, V132, P145

[15] COMPARISON OF FRESH AND PARAFFIN-EMBEDDED TISSUE AS STARTING MATERIAL FOR DNA FLOW-CYTOMETRY AND EVALUATION OF INTRATUMOR HETEROGENEITY [J].

KALLIONIEMI, OP .

CYTOMETRY, 1988, 9 (02) :164-169

[16]

LINDAHL B, 1987, ANTICANCER RES, V7, P791

[17] THE PROGNOSTIC-SIGNIFICANCE OF DNA MEASUREMENTS IN ENDOMETRIAL CARCINOMA [J].

MOBERGER, B ;

AUER, G ;

FORSSLUND, G ;

MOBERGER, G .

CYTOMETRY, 1984, 5 (04) :430-436

[18]

MOLINA R, 1992, ANTICANCER RES, V12, P1965

[19] EXPRESSION OF THE P185 ENCODED BY HER2 ONCOGENE IN NORMAL AND TRANSFORMED HUMAN TISSUES [J].

NATALI, PG ;

NICOTRA, MR ;

BIGOTTI, A ;

VENTURO, I ;

SLAMON, DJ ;

FENDLY, BM ;

ULLRICH, A .

INTERNATIONAL JOURNAL OF CANCER, 1990, 45 (03) :457-461

[20]

NEWBURY R, 1990, OBSTET GYNECOL, V76, P251

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