SYNTHESIS OF SUBSTITUTED DIHYDROBENZO[F]PYRIMIDO[4,5-B]-QUINOLINES AS TETRACYCLIC 5-DEAZA NONCLASSICAL FOLATES

被引：8

作者：

DONKOR, IO

GANGJEE, A

DUAH, FK

机构：

[1] DUQUESNE UNIV,SCH PHARM,PITTSBURGH,PA 15282

[2] MODAY CORP,DIV AGR CHEM,STILWELL,KS 66085

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1990年 / 27卷 / 03期

关键词：

D O I：

10.1002/jhet.5570270353

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cyclocondensation of 2,4,6‐triaminopyrimidine (10) with chlorovinyl aldehyde 7 afforded the linear regioisomer 9,1 1‐diamino‐5,6‐dihydrobenzo[f]pyrimido[4,5‐c]quinoline (1) while the cyclocondensation of 2,6‐diamino‐4‐hydroxypyrimidine (11) or 6‐amino‐2,4‐dihydroxypyrimidine (12) with chlorovinyl aldehyde 7 was regiospecific affording the linear regioisomers 9‐amino‐11‐oxo‐5,6‐dihydrobenzo[f]pyrimido[4,5‐c]quinoline (2) and 9,11‐dioxo‐5,6‐dihydrobenzo[f]pyrimido[4,5‐c]quinoline (3) respectively. The linear structures of these compounds were established by 1H nmr and 13C nmr spectral data. Copyright © 1990 Journal of Heterocyclic Chemistry

引用

页码：765 / 767

页数：3

共 17 条

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