CHROMOGRANIN-A PROCESSING IN SYMPATHETIC NEURONS AND RELEASE OF CHROMOGRANIN-A FRAGMENTS FROM SHEEP SPLEEN

被引：21

作者：

MISEREZ, B

ANNAERT, W

DILLEN, L

AUNIS, D

DEPOTTER, W ^{[1
]}

机构：

[1] UNIV INSTELLING ANTWERP, DEPT MED, NEUROPHARMACOL & NEUROBIOL LAB, UNIV PL 1, B-2610 WILRIJK, BELGIUM

[2] INSERM, U338, F-67084 STRASBOURG, FRANCE

来源：

FEBS LETTERS | 1992年 / 314卷 / 02期

关键词：

SYMPATHETIC NEURON; CHROMOGRANIN-A; VESICLE; PROCESSING; RELEASE;

D O I：

10.1016/0014-5793(92)80956-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chromogranin A (CGA) has been localized to the large dense cored vesicles (LDV) of sympathetic neurons. SDS-PAGE and immunoblotting of soluble LDV proteins from ox and dog adrenergic neuronal cell bodies, axons and nerve terminals, revealed an increasing number of CGA-immunoreactive forms, consistent with proteolytic processing during axonal transport. Splenic nerve electrical stimulation (10 Hz, 2 min) revealed that, apart from CGA, these CGA-processing products are released from the sheep spleen. The secretion of CGA-derived fragments from sympathetic neurons might suggest a role in the regulation of synaptic transmission.

引用

页码：122 / 124

页数：3

共 29 条

[1] CHROMOGRANIN-A - POSTTRANSLATIONAL MODIFICATIONS IN SECRETORY GRANULES [J].