INSULIN STIMULATES NOVEL PROTEIN-KINASE-C IN RAT ADIPOCYTES

被引：27

作者：

ISHIZUKA, T ^{[1
]}

YAMAMOTO, M ^{[1
]}

KAJITA, K ^{[1
]}

NAGASHIMA, T ^{[1
]}

YASUDA, K ^{[1
]}

MIURA, K ^{[1
]}

COOPER, DR ^{[1
]}

FARESE, RV ^{[1
]}

机构：

[1] JAMES A HALEY VET HOSP,TAMPA,FL 33612

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 183卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)90556-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Insulin is known to rapidly stimulate and/or translocate Ca2+ phospholipid-dependent protein kinase (conventional PKC; cPKC) in rat adipocytes. Presently we examined whether insulin also stimulates/translocates Ca2+-independent, phospholipid-dependent protein kinase (novel PKC; nPKC). Total Mono Q column-elutable nPKC (like cPKC) activities were decreased in cytosolic and increased in membrane fractions with insulin treatment. Immunoblot study of novel PKC ε also showed insulin-induced translocation of immunoreactive PKC from cytosol to membrane, similar to the translocation of cPKC, PKC β. These results suggest that nPKC has an important role in insulin-induced signal transduction. © 1992.

引用

页码：814 / 820

页数：7

共 22 条

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