ASSOCIATION OF A HOST DNA-STRUCTURE WITH RETROVIRAL INTEGRATION SITES IN CHROMOSOMAL DNA

被引：27

作者：

MILOT, E

BELMAAZA, A

RASSART, E

CHARTRAND, P

机构：

[1] CANADIAN RED CROSS BLOOD TRANSFUS SERV,RES & DEV MONTREAL CTR,MONTREAL H1W 1B2,PQ,CANADA

[2] UNIV MONTREAL,PROGRAM MOLEC BIOL,MONTREAL,PQ,CANADA

[3] UNIV QUEBEC,DEPT SCI BIOL,MONTREAL H3C 3P8,PQ,CANADA

来源：

VIROLOGY | 1994年 / 201卷 / 02期

关键词：

D O I：

10.1006/viro.1994.1310

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Integration of retroviral genomes is a site-specific process with respect to the virus but not the host genome. Numerous chromosomal sites and various sequences can be used as targets. Nevertheless, preferential regions and integration patterns have been observed. Using a functional assay, we investigated if host structural DNA elements could be associated with retroviral integration sites. The results were that 9 of 10 distinct retroviral integration events occurred in dose proximity of structural elements behaving like intrinsically bent DNA. (C) 1994 Academic Press, Inc.

引用

页码：408 / 412

页数：5

共 27 条

[1] DETECTION, SEQUENCE PATTERNS AND FUNCTION OF UNUSUAL DNA STRUCTURES [J].