EFFECTS OF APOCYNIN, A DRUG ISOLATED FROM THE ROOTS OF PICRORHIZA-KURROA, ON ARACHIDONIC-ACID METABOLISM

被引：87

作者：

ENGELS, F

RENIRIE, BF

THART, BA

LABADIE, RP

NIJKAMP, FP

机构：

[1] UNIV UTRECHT,FAC PHARM,DEPT PHARMACOGNOSY,3508 TD UTRECHT,NETHERLANDS

[2] TNO,INST APPL RADIOBIOL & IMMUNOL,DEPT CHRON & INFECT DIS,RIJSWIJK,NETHERLANDS

来源：

FEBS LETTERS | 1992年 / 305卷 / 03期

关键词：

APOCYNIN; ARACHIDONIC ACID METABOLISM; PROSTAGLANDIN; THROMBOXANE; PLATELET AGGREGATION;

D O I：

10.1016/0014-5793(92)80680-F

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apocynin is a constituent of root extracts of the medicinal herb Picrorhiza kurroa and has been shown to possess anti-inflammatory properties. We investigated the effects of apocynin on the production of arachidonic acid-derived inflammatory mediators by guinea pig pulmonary macrophages. Apocynin concentration-dependently inhibited the formation of thromboxane A2, whereas the release of prostaglandins E2 and F2-alpha was stimulated. Apocynin potently inhibited arachidonic acid-induced aggregation of bovine platelets, possibly through inhibition of thromboxane formation. The present results suggest that apocynin might, beside its therapeutic effects in inflammatory conditions when given in a root extract of P. kurroa, also be a valuable tool in the development of new anti-inflammatory or anti-thrombic drugs.

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页码：254 / 256

页数：3

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