ANTIGENIC MIMICRY OF AN IMMUNOGLOBULIN-A EPITOPE BY A HEPATITIS-B VIRUS-CELL ATTACHMENT SITE

被引：26

作者：

NEURATH, AR

STRICK, N

机构：

[1] The Lindsley F. Kimball Research Institute, The New York Blood Center, New York, NY 10021

来源：

VIROLOGY | 1990年 / 178卷 / 02期

关键词：

D O I：

10.1016/0042-6822(90)90368-2

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The preS(21-47) sequence of the hepatitis B virus (HBV) envelope protein is involved in binding of the virus to cell receptors. A protein similarity search revealed a partial homology between this sequence and a segment of the human immunoglobulin A (IgA) heavy chain constant region, suggesting that the cell attachment site for HBV might be located on secretory component representing a receptor for polymeric IgA. Data presented herein do not support this hypothesis but provide evidence for immunological cross-reactivity between IgA and the preS(21-47) region of the HBV env protein. © 1990.

引用

页码：631 / 634

页数：4

共 28 条

[21] VIRUS-INDUCED AUTOIMMUNITY - MOLECULAR MIMICRY AS A ROUTE TO AUTOIMMUNE-DISEASE [J].