COMBINATION THERAPY WITH PLATINUM AND ETOPOSIDE OF BRAIN METASTASES FROM BREAST-CARCINOMA

被引：84

作者：

COCCONI, G

LOTTICI, R

BISAGNI, G

BACCHI, M

TONATO, M

PASSALACQUA, R

BONI, C

BELSANTI, V

BASSI, P

机构：

[1] UNIV HOSP PERUGIA,DIV MED ONCOL,PERUGIA,ITALY

[2] ITALIAN ONCOL GRP CLIN RES,PARMA,ITALY

[3] UNIV HOSP PARMA,NEURORADIOL SERV,PARMA,CA

[4] ITALIAN ONCOL GRP CLIN RES,PERUGIA,ITALY

来源：

CANCER INVESTIGATION | 1990年 / 8卷 / 3-4期

关键词：

D O I：

10.3109/07357909009012049

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Twenty-two consecutive patients with brain metastases from breast carcinoma were treated with a combination of platinum (100 mg/m2 day 1) and etoposide (100 mg/m2 days 4,6,8) every three weeks. Five (23% achieved a complete response (CR) while 7 (32% obtained a partial response (PR) for an overall response rate of 55% The 95% confidence interval for combined CR and PR was 34-76% Five patients received brain irradiation after reaching the maximum degree of objective remission by chemotherapy. Median duration of combined CR plus PR was 40 weeks (12 + 152). Median duration of survival was 58 weeks (2; 208+ Fifty-five percent of the patients were alive at one year. Our study demonstrates that this combination treatment is highly effective in the management of brain metastases from breast carcinoma. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：327 / 334

页数：8

共 47 条

[21] BREAST-CARCINOMA - PATTERN OF METASTASIS AT AUTOPSY [J].