EFFECTS OF ARSENITE ON HEPATIC MIXED-FUNCTION OXIDASE ACTIVITY IN RATS

被引：31

作者：

ALBORES, A

CEBRIAN, ME

CONNELLY, JC

BACH, PH

BRIDGES, JW

机构：

[1] UNIV SURREY,ROBENS INST,TOXICOL UNIT,GUILDFORD GU2 5XH,SURREY,ENGLAND

[2] POLYTECH E LONDON,FAC SCI,LONDON E15 4LZ,ENGLAND

来源：

XENOBIOTICA | 1992年 / 22卷 / 05期

关键词：

D O I：

10.3109/00498259209053122

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Injection of arsenite (As3+) to control rats results in losses of total hepatic cytochrome P-450 and significant decreases of ethoxycoumarin O-deethylase (ECOD) and ethoxyresorufin O-deethylase (EROD) activities. However, As3+ appears to decrease the activity of these enzymes differentially, with EROD showing greater sensitivity than ECOD. 2. Injection of As3+ to rats treated with phenobarbital and isosafrole significantly decreases the total content of hepatic cytochrome P-450 and various mixed function oxidase (MFO) activities, with the exception of ECOD which appears to be insensitive to As3+. 3. 3-Methylcholanthrene administration apparently protects against the effects of As3+ on the cytochrome P-450 system, since total content of the cytochrome P-450 and various MFO activities were all insensitive to this treatment.

引用

页码：591 / 597

页数：7

共 17 条

[1] SODIUM ARSENITE INDUCED ALTERATIONS IN BILIRUBIN EXCRETION AND HEME METABOLISM [J].