TG (9 HSA-MYC), A HOMOZYGOUS LETHAL INSERTION IN THE MOUSE

被引：6

作者：

TUTOIS, S

SALAUN, J

MATTEI, MG

GUENET, JL

机构：

[1] INST PASTEUR,UNITE GENET MAMMIFERES,F-75724 PARIS 15,FRANCE

[2] INST EMBRYOL CELLULAIRE & MOLEC,F-94736 NOGENT SUR MARNE,FRANCE

[3] HOP ENFANTS LA TIMONE,INST NATL SANTE & RECH MED,F-13385 MARSEILLE 5,FRANCE

来源：

MAMMALIAN GENOME | 1991年 / 1卷 / 03期

关键词：

D O I：

10.1007/BF00351065

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transgenic mice generated with different DNA sequences were surveyed for possible homozygous mutant phenotypes. We found an embryonic lethal mutation in the transgenic mouse strain (MT-MYC12.4) containing the human c-myc gene. Embryos homozygous for the transgene die shortly after implantation. The strain MT-MYC12.4 carries approximately 50 tandem copies of the recombinant plasmid sequence. The 3' flanking sequence has been cloned and analyzed. It contains a unique sequence that has been conserved during evolution and maps to Chromosome (Chr) 9. This mutant has been designated Tg 9 (HSA-MYC).

引用

页码：184 / 190

页数：7

共 37 条

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