DIRECT SEPARATION OF ENANTIOMERS USING MULTIPLE-INTERACTION CHIRAL STATIONARY PHASES BASED ON THE MODIFIED BETA-CYCLODEXTRIN-BONDED STATIONARY PHASE

被引：19

作者：

LI, S ^{[1
]}

PURDY, WC ^{[1
]}

机构：

[1] MCGILL UNIV,DEPT CHEM,MONTREAL H3A 2K6,QUEBEC,CANADA

来源：

JOURNAL OF CHROMATOGRAPHY | 1992年 / 625卷 / 02期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/0021-9673(92)85192-V

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Several multiple-interaction chiral stationary phases have been developed. These stationary phases contain a hydrophobic cavity capable of inclusion complexation, aromatic groups capable of pi-pi interaction, polar hydroxyl groups capable of hydrogen-bonding with the polar functional groups of the solute, and bulky non-polar groups providing steric repulsion. The characteristics and properties of these stationary phases are described. The direct separation of enantiomers of a wide variety of chiral compounds are reported. The effect of mobile phase composition on the retention and resolution is discussed.

引用

页码：109 / 120

页数：12

共 24 条

[1]

Armstrong D. W., 1985, US Pat., Patent No. [4 539 399, 4539399, 4,539,399]

[2] SEPARATION OF DRUG STEREOISOMERS BY THE FORMATION OF BETA-CYCLODEXTRIN INCLUSION COMPLEXES [J].